Keywords
Genetics
Sleep quality
Polymorphism, genetic
How to Cite
Abstract
Sleep is a fundamental biological function, and any disturbances can lead to alterations in an individual’s physical, occupational, cognitive, and social functioning. Aim: This study aimed to evaluate the quality of sleep and its association with factors such as age, sex, facial profile, and genetic polymorphisms in individuals who underwent dental treatment. Methods: The study comprised a total of 227 individuals. The “Sleep Assessment Questionnaire” was utilized to evaluate sleep quality. For the genetic assessment, oral mucosa cells were collected and markers from the COMT (rs174675, rs165656), HTR2A (rs4941573, rs6313), and FKBP5 (rs1360780, rs3800373) genes were selected for real-time PCR analysis. The data were subjected to statistical analysis with a significance level of 0.05. Results: The results showed that women had a poorer perception of sleep quality (p<0.05). There was a significant association between sleep quality and facial profile (p<0.05). Individuals with facial profiles I and II had a poorer perception of sleep quality in general and in the domains of non-restorative sleep, sleep time disturbance, and restlessness. Individuals with facial profile II had a poorer perception of sleep apnea than those with profile III (p=0.034). There was a significant association between the COMT rs174675 polymorphism and restlessness (p=0.035). Conclusion: The poorest perception of sleep quality was associated with women and individuals with facial profiles I and II. The poorest perception of restlessness was associated with COMT rs174675 polymorphism.
References
Steiger A, Pawlowski M. Depression and sleep. Int J Mol Sci. 2019 Jan;20(3):607. doi: 10.3390/ijms20030607.
Chang AM, Aeschbach D, Duffy JF, Czeisler CA. Evening use of light-emitting eReaders negatively affects sleep, circadian timing, and next-morning alertness. Proc Natl Acad Sci U S A. 2015 Jan;112(4):1232-7. doi: 10.1073/pnas.1418490112. Epub 2014 Dec 22.
Shiomi FK, Pisa IT, de Campos CJR. Computerized analysis of snoring in sleep apnea syndrome. Braz J Otorhinolaryngol. 2011 Jul-Aug;77(4):488-98. doi: 10.1590/S1808-86942011000400013.
Rahe C, Czira ME, Teismann H, Berger K. Associations between poor sleep quality and different measures of obesity. Sleep Med. 2015 Oct;16(10):1225-8. doi: 10.1016/j.sleep.2015.05.023.
Brockmann PE, Damiani F, Gozal D. Sleep-disordered breathing in adolescents and younger adults: a representative population-based survey in Chile. Chest. 2016 Apr;149(4):981-90. doi: 10.1378/chest.15-2112.
Binder EB, Salyakina D, Lichtner P, Wochnik GM, Ising M, Pütz B, et al. Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. Nat Genet. 2004 Dec;36(12):1319-25. doi: 10.1038/ng1479.
Jiang Y, Tang J, Li R, Zhao J, Song Z, Ge H, et al. Effect of 5-HT2A receptor polymorphisms, work stressors, and social support on job strain among petroleum workers in Xinjiang, China. Int J Environ Res Public Health. 2016 Dec;13(12):1258. doi: 10.3390/ijerph13121258.
Zannas AS, Wiechmann T, Gassen NC, Binder EB. Gene-stress-epigenetic regulation of FKBP5: clinical and translational implications. Neuropsychopharmacology. 2016 Jan;41(1):261-74. doi: 10.1038/npp.2015.235. Epub 2015 Aug 13.
Dean AG, Sullivan KM, Soe MM. OpenEpi: Open Source Epidemiologic Statistics for Public Health. Version 3.01. [cited 2023 Jul 31]. Available from: www.OpenEpi.com.
Machado AV, Castro CO, Botelho Filho CR, Bruzamolin CD, Scariot R, Pizzatto E, et al. Anxiety and Sleep Quality in Dental Students at a Private Brazilian University. Bull Tokyo Dent Coll. 2020 Mar 12;61(1):27-36. doi: 10.2209/tdcpublication.2018-0072.
Capelozza Filho L. Diagnóstico em Ortodontia. Maringá: Dental Press; 2004. 512p.
Oliveira LK, Almeida Gde A, Lelis ÉR, Tavares M, Fernandes Neto AJ. Temporomandibular disorder and anxiety, quality of sleep, and quality of life in nursing professionals. Braz Oral Res. 2015;29:S1806-83242015000100265. doi: 10.1590/1807-3107BOR-2015.vol29.0070.
Togeiro SM, Smith AK. [Diagnostics methods for sleep disorders]. Braz J Psychiatry. 2005 May;27 Suppl 1:8-15. Portuguese. doi: 10.1590/s1516-44462005000500003.
Mainieri VC, Saueressig AC, Fagondes SC, Teixeira ER, Rehm DD, Grossi ML. Analysis of the effects of a mandibular advancement device on sleep bruxism using polysomnography, the BiteStrip, the sleep assessment questionnaire, and occlusal force. Int J Prosthodont. 2014 Mar-Apr;27(2):119-26. doi: 10.11607/ijp.3675.
Castro Mattia PR, Panitz Selaimen CM, Teixeira ER, Fagondes SC, Grossi ML. The effects of sleeping with or without prostheses on sleep quality, sleep bruxism, and signs of obstructive sleep apnea syndrome: a pilot study. Int J Prosthodont. 2018 May/Jun;31(3):197-205. doi: 10.11607/ijp.5401.
Selaimen C, Brilhante D, Grossi ML. Evaluation of the Sleep Assessment Questionnaire (SAQ) in patients with temporomandibular disorders. Rev Odonto Cienc 2004;19(45):224-32.
Cesta A, Moldofsky H, Sammut C. The sensitivity and specificity of the Sleep Assessment Questionnaire (SAQ) as a measure of non-restorative sleep. Sleep Med Rev. 1999;(3):1-4.
Cesta A, Moldofsky H, Sammut C. The University of Toronto Sleep Assessment Questionnaire (SAQ). Sleep Res. 1996;25:486.
Trevilatto PC, Line SR. Use of buccal epithelial cells for PCR amplification of large DNA fragments. J Forensic Odontostomatol. 2000 Jun;18(1):6-9.
Aidar M, Line SR. A simple and cost-effective protocol for DNA isolation from buccal epithelial cells. Braz Dent J. 2007;18(2):148-52. doi: 10.1590/s0103-64402007000200012.
Barros MBA, Lima MG, Ceolim MF, Zancanella E, Cardoso TAMO. Quality of sleep, health and well-being in a population-based study. Rev Saude Publica. 2019 Sep 30;53:82. doi: 10.11606/s1518-8787.2019053001067.
Hoefelmann LP, Lopes Ada S, Silva KS, Silva SG, Cabral LG, Nahas MV. Lifestyle, self-reported morbidities, and poor sleep quality among Brazilian workers. Sleep Med. 2012 Oct;13(9):1198-201. doi: 10.1016/j.sleep.2012.05.009.
Baker FC, Wolfson AR, Lee KA. Association of sociodemographic, lifestyle, and health factors with sleep quality and daytime sleepiness in women: findings from the 2007 National Sleep Foundation "Sleep in America Poll". J Womens Health (Larchmt). 2009 Jun;18(6):841-9. doi: 10.1089/jwh.2008.0986.
Doi Y, Minowa M, Uchiyama M, Okawa M. Subjective sleep quality and sleep problems in the general Japanese adult population. Psychiatry Clin Neurosci. 2001 Jun;55(3):213-5. doi: 10.1046/j.1440-1819.2001.00830.x.
Brevi B, Di Blasio A, Di Blasio C, Piazza F, D'Ascanio L, Sesenna E. Which cephalometric analysis for maxillo-mandibular surgery in patients with obstructive sleep apnoea syndrome? Acta Otorhinolaryngol Ital. 2015 Oct;35(5):332-7. doi: 10.14639/0392-100X-415.
Boyd SB. Management of obstructive sleep apnea by maxillomandibular advancement. Oral Maxillofac Surg Clin North Am. 2009 Nov;21(4):447-57. doi: 10.1016/j.coms.2009.09.001.
George LT, Barber HD, Smith BM. Maxillomandibular advancement surgery: an alternative treatment option for obstructive sleep apnea. Atlas Oral Maxillofac Surg Clin North Am. 2007 Sep;15(2):163-77. doi: 10.1016/j.cxom.2007.05.006.
Tomonari H, Takada H, Hamada T, Kwon S, Sugiura T, Miyawaki S. Micrognathia with temporomandibular joint ankylosis and obstructive sleep apnea treated with mandibular distraction osteogenesis using skeletal anchorage: a case report. Head Face Med. 2017 Nov;13(1):20. doi: 10.1186/s13005-017-0150-4.
Dauvilliers Y, Tafti M, Landolt HP. Catechol-O-methyltransferase, dopamine, and sleep-wake regulation. Sleep Med Rev. 2015 Aug;22:47-53. doi: 10.1016/j.smrv.2014.10.006. Epub 2014 Oct 27.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2024 Elvira Katherine Barriga Flores , Marina Fanderuff , Katheleen Miranda dos Santos , Michelle Nascimento Meger, Delson João d Costa , Carmen Lucia Mueller Storrer, Rafaela Scariot