@article{Valderramas_Moura_Couto_Pasetto_Chierice_Guimarães_Zurron_2015, place={Limeira, SP}, title={Antiinflammatory activity of ricinus communis derived polymer}, volume={7}, url={https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8642494}, DOI={10.20396/bjos.v7i27.8642494}, abstractNote={Aim: The present study aimed to evaluate the antiinflammatory activity of the polymer derived from Ricinus communis and its mechanism of action. Methods: The antiinflammatory activity was investigated in chronic and acute animal models and the mechanism of action involved in the antiinflammatory activity was determined by the in vitro phospholipase A2 (PLA2 ) enzyme assay. Results: In mouse ear edema (10.0 mg/ear) and granulomatous tissue formation (500 mg/kg) models, the polymer inhibited the inflammatory response in 75.08 ± 1.80% and 61.70 ± 1.80% of the cases, respectively (p<0.001). Oral administration of the Ricinus communis polymer (500 mg/kg) inhibited 72.00 ± 1.20% of formalin-induced inflammation. Topical administration of the polymer on oral lesions of mice showed that the oral mucosa was recovered in 60.00 ± 1.40% (p<0.05) of the cases. In in vitro assay, the phospholipase A2 enzyme was inhibited by the Ricinus communis polymer (5.0 mg/mL) in a dose-dependent manner (84.60 ± 1.41%). Conclusion: the polymer derived from Ricinus communis showed a significant antiinflammatory activity, confirming that the pharmacological mechanism involved in this antiinflammatory action was related to the inhibition of the PLA2 enzyme.}, number={27}, journal={Brazilian Journal of Oral Sciences}, author={Valderramas, Adriana Cristina and Moura, Sérgio Henrique Pereira and Couto, Maira and Pasetto, Silvana and Chierice, Gilberto Orivaldo and Guimarães, Sérgio Augusto Catanzaro and Zurron, Ana Claudia Bensuaski de Paula}, year={2015}, month={Dec.}, pages={1666–1672} }