TY - JOUR AU - Souto, Giovanna Ribeiro AU - Jesus, Alessandro Oliveira de AU - Kato Segundo, Takeshi AU - Perdigão, Paôlla Freitas AU - Costa, Fernando de Oliveira AU - Mesquita, Ricardo Alves de PY - 2019/09/10 Y2 - 2024/03/29 TI - Mast cell degranulation in periodontal disease from HIV-infected individuals JF - Brazilian Journal of Oral Sciences JA - Braz. J. Oral Sci. VL - 18 IS - SE - Article DO - 10.20396/bjos.v18i0.8656600 UR - https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8656600 SP - e191445 AB - <p>Aim: The objective was to compare the density and degranulation of mast cells on specimens obtained from individuals diagnosed with gingivitis or chronic periodontitis who were either non-HIV-infected or HIV-infected patients treated with highly active antiretroviral therapy (HAART). Methods: Gingival samples were taken from 16 non-HIV-infected individuals and 17 HIV-infected individuals diagnosed with gingivitis and chronic periodontitis. The samples were processed and stained with 0.3 percent o-toluidine blue. Densities (cells/mm²) and percentages of intact and degranulated mast cells were obtained. Results: No statistically significant differences were observed in the mast cell density and the percentage of degranulated mast cells between non-HIV-infected and HIV-infected individuals diagnosed with gingivitis and chronic periodontitis. Mononuclear inflammatory infiltrate was weakly correlated with the percentage of mast cells degranulated for both groups. Conclusions: There are no differences of the density and degranulation of mast cells in gingival tissue between non-HIV-infected and HIV-infected patients undergoing HAART, both groups with diagnosis of gingivitis or chronic periodontitis. This may be a result of the recovery of the immunologic system by HAART treatment.</p> ER -