TY - JOUR AU - Stolf, Camila Schmidt AU - Taiete, Tiago AU - Zaffalon Casati, Márcio AU - Sallum, Enílson Antônio AU - Nociti Júnior, Francisco Humberto AU - Ruiz, Karina Gonzales Silvério AU - Casarin, RenatoCorrêa Viana PY - 2021/02/08 Y2 - 2024/03/28 TI - Influence of rs6667202 SNP on Interleukin-10 levels in the gingival fluid of patients with periodontitis grade C JF - Brazilian Journal of Oral Sciences JA - Braz. J. Oral Sci. VL - 20 IS - 00 SE - Original Research DO - 10.20396/bjos.v20i00.8661654 UR - https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8661654 SP - e211654 AB - <p>Grade C periodontitis in youngers is characterized by a severe form of periodontitis, and <em>IL10 </em>rs6667202 single nucleotide polymorphism (SNP) has been described as an important feature in this disease etiology. Aim: This study aimed to evaluate, in vivo, the functionality of <em>IL10 </em>rs6667202 SNP on IL-10 gingival fluid levels. Methods: Thirty patients with Perio4C were selected, 15 with the <em>IL10 </em>AA genotype (rs6667202) and 15 with AC/CC genotypes. The gingival fluid was collected from two sites with probing depth ≥ 7 mm and bleeding on probing, and two healthy sites. The IL-10 concentration was determined by Luminex/MAGpix platform. Results: In deep pockets, the <em>IL10 </em>AA genotype presented a lower concentration of IL-10 when compared with AC or CC genotypes (p&lt;0.05). In shallow pockets, no difference between groups was seen (p&gt;0.05). Conclusion: <em>IL10 </em>rs6667202 SNP decreases the production of IL-10 in crevicular fluid, potentially affecting this disease progression.  </p> ER -