Use of etoricoxib and dexamethasone for postoperative pain prevention and control in mucogingival surgery - A randomized parallel double-blind clinical trial

Authors

  • Ligia Nadal Zardo State University of Ponta Grossa
  • Fábio André dos Santos State University of Ponta Grossa
  • Gibson Luiz Pilatti State University of Ponta Grossa

DOI:

https://doi.org/10.20396/bjos.v12i4.8640981

Keywords:

Analgesia, Pain, Postoperative, Surgery, oral

Abstract

Aim: To compare the use of etoricoxib and dexamethasone for postoperative pain prevention and control after mucogingival surgery. Methods: Fifty-eight patients with indication for mucogingival surgery took part in this randomized parallel double-blind clinical trial. They were divided into three groups (G): G1 – placebo 1 h before surgery; G2 – 8 mg dexamethasone 1 h before surgery; G3 – 90 mg etoricoxib 1 h before surgery. Pain intensity was assessed in donor and recipient sites separately using the 101-point numerical rating scale NRS – 101, every hour for the first 8 h after surgery and three times a day on the following 3 days. Results: there was a statistically significant difference in the postoperative pain intensity in the donor site between G1 and G3 after 1 h, 2 h, 3 h, 7 h, 8 h and on the second day – in the evening after 32 h; between G1 and G2 after 2 h and 3 h, and between G2 and G3 only after the first hour. Pain intensity in the recipient site was statistically significant between G1 and G3 after 1 and 2 h (p<0.05). In addition, there was a lower ingestion of rescue medication in G2 and in G3 than in G1 (p=0.002). Conclusions: the use of a pre-emptive single dose of etoricoxib or dexamethasone may be considered an effective protocol for postoperative pain prevention and control after mucogingival surgery.

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Author Biographies

Ligia Nadal Zardo, State University of Ponta Grossa

Department of Periodontology, Dental School, State University of Ponta Grossa, Ponta Grossa, PR.

Fábio André dos Santos, State University of Ponta Grossa

Department of Periodontology, Dental School, State University of Ponta Grossa, Ponta Grossa, PR.

Gibson Luiz Pilatti, State University of Ponta Grossa

Department of Periodontology, Dental School, State University of Ponta Grossa, Ponta Grossa, PR.

Published

2015-10-15

How to Cite

1.
Zardo LN, Santos FA dos, Pilatti GL. Use of etoricoxib and dexamethasone for postoperative pain prevention and control in mucogingival surgery - A randomized parallel double-blind clinical trial. Braz. J. Oral Sci. [Internet]. 2015 Oct. 15 [cited 2022 Aug. 14];12(4):345-51. Available from: https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8640981

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