Keratocystic odontogenic tumor related to nevoid basal cell carcinoma syndrome: clinicopathological study

Authors

  • Luana Eschholz Bomfin São Paulo University
  • Ana Paula M. Vivas São Paulo University
  • Andre Caroli Rocha A. C. Camargo Hospital
  • Maria Isabel W. Achatz A. C. Camargo Hospital
  • Clovis Antonio L. Pinto A. C. Camargo Hospital
  • Fabio Abreu Alves University of São Paulo; A. C. Camargo Hospital

DOI:

https://doi.org/10.20396/bjos.v12i1.8641129

Keywords:

Gorlin Syndrome, Keratocyst, Keratocystic Odontogenic Tumor, Nevoid Basal Cell Carcinoma syndrome

Abstract

Aim: To assess clinicopathological features of patients with keratocystic odontogenic tumor (KCOT) associated with nevoid basal cell carcinoma syndrome (NBCCS) in a single Brazilian institution. Methods: After histopathological analyses of KCOT related to NBCCS, the medical charts of 14 patients were assessed. These patients presented a total of 31 primary and 8 recurrent KCOT. Results: Out of 14 patients, 8 presented a single KCOT, 4 showed synchronous tumors, 1 had 3 metachronous lesions and another patient had 2 synchronous lesions at initial evaluation and then developed other 3 metachronous lesions. Besides the 31 primary KCOTs, 18 lesions were located in mandible and 13 in maxilla. Most tumors presented unilocular pattern and association with a tooth. Conclusions: KCOT is a frequent manifestation of NBCCS and can be its first sign, mainly in young patients. In contrast to a previously published series, most patients presented a single lesion.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Author Biographies

Luana Eschholz Bomfin, São Paulo University

Department of Stomatology, São Paulo University, São Paulo, SP.

Ana Paula M. Vivas, São Paulo University

Department of Stomatology, São Paulo University, São Paulo, SP.

Andre Caroli Rocha, A. C. Camargo Hospital

Department of Stomatology, A. C. Camargo Hospital, São Paulo, SP.

Maria Isabel W. Achatz, A. C. Camargo Hospital

Department of Oncogenetics, A. C. Camargo Hospital, São Paulo, SP.

Clovis Antonio L. Pinto, A. C. Camargo Hospital

Department of Anatomical Pathology, A. C. Camargo Hospital, São Paulo, SP.

Fabio Abreu Alves, University of São Paulo; A. C. Camargo Hospital

Department of Stomatology, University of São Paulo, Department of Stomatology, A. C. Camargo Hospital, São Paulo, SP.

Published

2015-10-19

How to Cite

1.
Bomfin LE, Vivas APM, Rocha AC, Achatz MIW, Pinto CAL, Alves FA. Keratocystic odontogenic tumor related to nevoid basal cell carcinoma syndrome: clinicopathological study. Braz. J. Oral Sci. [Internet]. 2015 Oct. 19 [cited 2022 Nov. 30];12(1):23-9. Available from: https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8641129

Issue

Section

Article