Effect of cetylpyridinium chloride with xylitol on the formation of biofilm and development of gingivitis


  • Bruna Ghiraldini UNIP
  • Erika Tie Furushima UNIP
  • Renato Corrêa Viana Casarin UNIP
  • Karina Teixeira Villalpando PUC Campinas




Cetylpyridinium chloride, Xylitol, Gingivitis


Aim: To assess the effect of the combination of cetylpyridinium chloride and xylitol on the formation of dental biofilm and development of experimental gingivitis. Methods: A crossover, double-blind, placebo-controlled study was conducted and divided into two phases of 21 days each with a time interval of 10 days between them. A modified experimental gingivitis model was used and 31 volunteers were randomly divided into 2 groups. The volunteers performed daily mouthwashes twice a day with the test solution containing cetylpyridinium combined with xylitol or a placebo solution. On day 0 and day 21 of each phase the Plaque Index (PI) and Gingival Index (GI) of each volunteer were measured. During this phase, the volunteers brushed their teeth with standard toothbrushes and dentifrice, protecting the third quadrant with a toothshield. After brushing, the toothshield was removed and the mouthwash was used. Results: The PI values observed in the Test Group at baseline and on day 21 were 0 (0.00 – 0.03) and 0 (0.22-0.48) respectively, and in Control Group 0 (0.00 – 0.03) and 1 (0.45 – 0.81) (inter-group analysis - McNemar test, p<0.05). For GI, the values obtained in the Test Group were 0 (0.00 – 0.03) and 1 (0.48 – 0.71), at baseline and day 21 and in Control Group 0 (0.00 – 0.03) and 1 (0.58 – 0.84) (inter-group analysis - McNemar test, p>0.05). Conclusions: The test solution had a positive effect on dental biofilm control. However, it was not capable of preventing the development of experimental gingivitis.


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Author Biographies

Bruna Ghiraldini, UNIP

Dentist, UNIP, São Paulo, SP

Erika Tie Furushima, UNIP

Undergraduate student, UNIP, São Paulo, SP

Renato Corrêa Viana Casarin, UNIP

MsC, PhD, Professor of Periodontics, UNIP, São Paulo, SP

Karina Teixeira Villalpando, PUC Campinas

MsC, PhD, Professor of Periodontics and Dental Clinic, PUC, Campinas, SP.



How to Cite

Ghiraldini B, Furushima ET, Casarin RCV, Villalpando KT. Effect of cetylpyridinium chloride with xylitol on the formation of biofilm and development of gingivitis. Braz. J. Oral Sci. [Internet]. 2015 Oct. 27 [cited 2023 Feb. 7];11(3):392-5. Available from: https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8641379




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