Effect of crude extract and essential oil of Cordia verbenacea in experimental periodontitis in rats

Authors

  • Fernanda Vieira Ribeiro Paulista University
  • Guilherme Emerson Barrella Paulista University
  • Renato Corrêa Viana Casarin Paulista University
  • Fabiano Ribeiro Cirano Paulista University
  • Mary Ann Foglio University of Campinas
  • Suzana Peres Pimentel Paulista University

DOI:

https://doi.org/10.20396/bjos.v11i1.8641547

Keywords:

Alveolar bone loss, Cordia, Inflammation, Periodontitis

Abstract

Aim: To evaluate the effect of crude extract and essential oil of Cordia verbenacea (C.V.), systemically administered, on ligature-induced periodontitis in rats. Methods: Periodontitis was induced in 54 Wistar rats: one of the first mandibular molars was randomly assigned to receive a ligature, whereas the contralateral molar was left unligated. Then, animals were randomly assigned to one of the following groups: non-treatment group (n=18): animals that received 10 mL/day of vehicle; C.V. extract group (n=18): animals that received 100 mg/kg/day of crude extract of C. verbenacea; and C.V. essential oil group (n=18): animals that received 100 mg/kg/day of essential oils free of C. verbenacea. All therapies were administered orally 3 times daily, for 11 days. Next, the animals were sacrificed, and the specimens were processed for morphometric analysis. Bone loss was determined on the buccal surface of the lower first molars by the distance of the cementoenamel junction from the alveolar bone. Results: Both extract and essential oil of C. verbenacea orally administered decreased alveolar bone loss in the ligated teeth when compared with the non-treated group (p<0.05). Conclusions: The present study demonstrated that systemic administration of both formulations of Cordia verbenacea may attenuate the progression of ligatureinduced periodontitis.

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Author Biographies

Fernanda Vieira Ribeiro, Paulista University

DDS, MS, PhD, Professor, Dental Research Division, Department of Periodontology, School of Dentistry, Paulista University

Guilherme Emerson Barrella, Paulista University

DDS, MS Student, Dental Research Division, Department of Periodontology, School of Dentistry, Paulista University

Renato Corrêa Viana Casarin, Paulista University

DDS, MS, PhD, Professor, Dental Research Division, Department of Periodontology, School of Dentistry, Paulista University

Fabiano Ribeiro Cirano, Paulista University

DDS, MS, PhD, Professor, Dental Research Division, Department of Periodontology, School of Dentistry, Paulista University

Mary Ann Foglio, University of Campinas

DDS, MS, PhD, Professor, Multidisciplinary Center for Chemical, Biological and Agricultural Research (CPQBA), University of Campinas

Suzana Peres Pimentel, Paulista University

DDS, MS, PhD, Professor, Dental Research Division, Department of Periodontology, School of Dentistry, Paulista University

Published

2015-11-03

How to Cite

1.
Ribeiro FV, Barrella GE, Casarin RCV, Cirano FR, Foglio MA, Pimentel SP. Effect of crude extract and essential oil of Cordia verbenacea in experimental periodontitis in rats. Braz. J. Oral Sci. [Internet]. 2015 Nov. 3 [cited 2022 Sep. 30];11(1):42-6. Available from: https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8641547

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