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Absence of mutations in the promoter region of the lef1 gene in Patients with hypodontia
Vol. 2 No. 4 (2003), Article
Vol. 2 No. 4 (2003)

Absence of mutations in the promoter region of the lef1 gene in Patients with hypodontia

Article
https://doi.org/10.20396/bjos.v2i4.8641664
Published 2015-11-11
Elisângela R. Silva
Department of Morphology, Faculty of Odontology of Piracicaba - UNICAMP –
Regina C. R. Peres
Department of Morphology, Faculty of Odontology of Piracicaba - UNICAMP
Raquel M. Scarel-Caminaga
Division of Oral Biology, University of Sagrado Coração-USC
Ferdinando De Conto
Department of Morphology, Faculty of Odontology of Piracicaba - UNICAMP
Sergio R. P. Line
Department of Morphology, Faculty of Odontology of Piracicaba - UNICAMP
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Keywords

LEF1. Homeobox. Hypodontia. Tooth agenesis

How to Cite

1.
Silva ER, Peres RCR, Scarel-Caminaga RM, De Conto F, Line SRP. Absence of mutations in the promoter region of the lef1 gene in Patients with hypodontia. Braz. J. Oral Sci. [Internet]. 2015 Nov. 11 [cited 2024 Jul. 4];2(4):144-6. Available from: https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8641664
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Abstract

Hypodontia, the congenital absence of one or a few permanent teeth, is one of the most frequent alterations of the human dentition. Although hypodontia does not represent a public health problem, it may cause both, speech and masticatory dysfunction as well as esthetic problems. Ablation of Lef1 gene in mice causes complete loss of teeth and interferes with the development of other structures induced by epithelial-mesenchymal interaction. In order to further investigate the role of the Lef1 gene in human hypodontia we analyzed the promoter region of the Lef1 gene in 50 subjects with different patterns of hypodontia and 50 control individuals. The analysis of single strand conformation polymorphism (SSCP) did not show any polymorphisms/mutations in the region analyzed.
https://doi.org/10.20396/bjos.v2i4.8641664
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