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Factors associated with early and late failure of osseointegrated implant


Peri-implantitis. Implant failure. Implant therapy. Dental implant

How to Cite

Cury PR, Sendyk WR, Sallum AW. Factors associated with early and late failure of osseointegrated implant. Braz. J. Oral Sci. [Internet]. 2015 Nov. 12 [cited 2024 Mar. 3];2(6):233-8. Available from:


The use of dental implants in the rehabilitation of partially and fully edentulous patients is an efficient method even though failures do occur. Papers have speculated on the cause of failure. Bone quality and quantity, shorter implants, smoking and systemic health, surgical trauma, contamination during implant surgery, peri-implantitis, and overloading throughout the prosthesis have been associated with failures. The aim of the present review is to analyze the possible causes of implant failure.


Adell R, Eriksson B, Lekholm U, Brånemark P-I, Jemt T. A long-term follow-up study of osseointegrated implants in the treatment of totally edentulous jaws. Int J Oral Maxillofac Surg 1990; 5: 347–59.

Albrektsson T, Dahl E, Enbom L, Engevall S, Engquist B, Eriksson AR, et al. Osseointegrated oral implants: A Swedish multicenter study of 8139 consecutively inserted Nobelpharma implants. J Periodontol 1988; 59: 287–96.

Bain C, Moy P. The association between the failure of dental implants and cigarette smoking. Int J Oral Maxillofac Surg 1993; 8: 609–15.

De Bruyn H, Callaert B. The effect of smoking on early implant failure. Clin Oral Impl Res 1994; 5: 260–4.

Zarb GA, Schmitt A. The longitudinal clinical effectiveness of osseointegrated dental implants: The Toronto study. Part III: Problems and complications encountered. J Prosthet Dent 1990; 64: 185–94.

Naert I, Quirynen M, van Steenberghe D, Darius P. A study of 589 consecutive implants supporting complete fixed prostheses. Part II: Prosthetic aspects. J Prosthet Dent 1992; 68: 949-56.

Apse P, Zarb G, Schmitt A, Lewis D. The longitudinal effectiveness of osseointegrated dental implants. The Toronto study: Peri-implant mucosal response. Int J Periodontics Restorative Dent 1991; 11: 95–110.

Hutton JE, Heath MR, Chai JY, Harnett J, Jemt T, Johns RB, et al. Factors related to success and failure rates at 3- year follow-up in a multicenter study of overdentures supported by Brånemark implants. Int J Oral Maxillofac Implants 1995; 10: 33–42.

Friberg B, Jemt T, Lekohlm U. Early failures in 4,641 consecutively placed Brånemark dental implants: A study from stage 1 surgery to the connection of completed prosthesis. Int J Oral Maxillofac Implants 1991; 6: 142–6.

Khang W, Feldman S, Hawley CE, Gunsolley J. A multicenter study comparing dual acid-etched and machinedsurfaced implants in various bone qualities. J Periodontol 2001; 72: 1384-90.

Buser D, Weber H-P, Bragger U, Balsiger C. Tissue integration of one-stage ITI implants: 3-year results of a longitudinal study with hollow-cylinder and hollow-screw implants. Int J Oral Maxillofac Implants 1991; 6: 405–12.

Jemt T, Lekholm U. Implant treatment in edentulous maxillae: A 5-year follow-up report on patients with different degrees of jaw resorption. Int J Oral Maxillofac Implants 1995; 10: 303–11.

Weyant R, Burt BA. An assessment of survival rates and within-patient clustering of failures for endosseous oral implants. J Dent Res 1993;72: 2–8.

Esposito M, Hirsch JM, Lekholm U, Thomsen P. Biological factors contributing to failures of osseointegrated oral implants. (II). Etiopathogenesis. Eur J Oral Sci 1998; 106: 721-64.

Eriksson RA, Albrektsson T. The effect of heat on bone regeneration: an experimental study in the rabbit using the bone growth chamber. J Oral Maxillofac Surg 1984; 42: 705-11.

Piattelli A, Scarano A, Piattelli M. Microscopical aspects of failure in osseointegrated dental implants: a report of five cases. Biomaterials 1996; 17: 1235-41.

Van Steenberghe D, Lekholm U, Bolender C, Folmer T, Henry P, Herrmann I, et al. Applicability of osseointegrated oral implants in the rehabilitation of partial edentulism: a prospective multicenter study on 558 fixtures. Int J Oral Maxillofac Implants 1990; 5: 272-81.

Weyant R. Characteristics associated with the loss and periimplant tissue health of endosseous dental implants. Int J Oral Maxillofac Implants 1994; 9: 95–102.

Lambert PM, Morris HF, Ochi S. The influence of smoking on 3-year clinical success of osseointegrated dental implants. Ann Periodontol 2000; 5: 79-89.

Olson JW, Dent CD, Morris HF, Ochi S. Long-term assessment (5 to 71 months) of endosseous dental implants placed in the augmented maxillary sinus. Ann Periodontol 2000; 5: 152-6.

Morris HF, Ochi S, Winkler S. Implant survival in patients with type 2 diabetes: placement to 36 months. Ann Periodontol 2000; 5: 157-65.

Farzad P, Andersson L, Nyberg J. Dental implant treatment in diabetic patients. Implant Dent 2002; 11: 262-7.

August M, Chung K, Chang Y, Glowacki J. Influence of estrogen status on endosseous implant osseointegration. J Oral Maxillofac Surg 2001; 59: 1285-9.

Minsk L, Polson AM. Dental implant outcomes in postmenopausal women undergoing hormone replacement. Compend Contin Educ Dent 1998; 19: 859-62.

Friberg B, Ekestubbe A, Mellstrom D, Sennerby L. Branemark implants and osteoporosis: a clinical exploratory study. Clin Implant Dent Relat Res 2001; 3: 50-6.

Becker W, Hujoel PP, Becker BE, Willingham H. Osteoporosis and implant failure: an exploratory casecontrol study. J Periodontol 2000; 71: 625-31.

Kovacs AF. Influence of chemotherapy on endosteal implant survival and success in oral cancer patients. Int J Oral Maxillofac Surg 2001; 30: 144-7.

Goto M, Jin-Nouchi S, Ihara K, Katsuki T. Longitudinal follow-up of osseointegrated implants in patients with resected jaws. Int J Oral Maxillofac Implants 2002; 17: 225-30.

Werkmeister R, Szulczewski D, Walteros-Benz P, Joos U. Rehabilitation with dental implants of oral cancer patients. J Craniomaxillofac Surg 1999; 27: 38-41.

Wagner W, Esser E, Ostkamp K. Osseointegration of dental implants in patients with and without radiotherapy. Acta Oncol 1998; 37: 693-6.

Visch LL, van Waas MA, Schmitz PI, Levendag PC.A clinical evaluation of implants in irradiated oral cancer patients. J Dent Res 2002; 81: 856-9.

Swanberg DF, Henry MD.Avoiding implant overload. Implant Soc 1995; 6: 12-4.

. Isidor F. Histological evaluation of peri-implant bone at implants subjected to occlusal overload or plaque accumulation. Clin Oral Implant Res 1997; 8: 1-9.

Quirynen M, Naert I, van Steenberghe D. Fixture design and overload influence marginal bone loss and fixture success in the Branemark system. Clin Oral Implants Res 1992; 3: 104-11.

Esposito M, Thomsen P, Ericson LE, Sennerby L, Lekholm U. Histopathologic observations on late oral implant failures. Clin Implant Dent Relat Res 2000; 2: 18-32.

Lang NP, Wilson TG, Corbet EF. Biological complications with dental implants: their prevention, diagnosis and treatment. Clin Oral Implants Res 2000; 11: 146-55.

Eke PI, Braswell LD, Fritz ME. Microbiota associated with experimental peri-implantitis and periodontitis in adult Macaca mulatta monkeys. J Periodontol 1998; 69: 190-4.

Marchetti C, Farina A, Cornaglia AI. Microscopic, immunocytochemical, and ultrastructural properties of periimplant mucosa in humans. J Periodontol 2002; 73: 555- 563.

Jemt T, Lekholm U. Oral implant treatment in posterior partially edentulous jaws: a 5-year follow-up report. Int J Oral Maxillofac Implants 1993; 8: 635-40.

Olsson M, Gunne J, Astrand P, Borg K. Bridges supported by free-standing implants versus bridges supported by tooth and implant. A five-year prospective study. Clin Oral Implants Res 1995; 6: 114-21.

Jemt T, Lekholm U, Adell R. Osseointegrated implants in the treatment of partially edentulous patients: a preliminary study on 876 consecutively placed fixtures. Int J Oral Maxillofac Implants 1989; 4: 211-7.

Adell R, Lekholm U, Grondahl K, Branemark PI, Lindstrom J, Jacobsson M. econstruction of severely resorbed edentulous maxillae using osseointegrated fixtures in immediate autogenous bone grafts. Int J Oral Maxillofac Implants 1990; 5: 233-46.

Astrand P, Borg K, Gunne J, Olsson M. Combination of natural teeth and osseointegrated implants as prosthesis abutments: a 2-year longitudinal study. Int J Oral Maxillofac Implants 1991; 6: 305-12.

Oh TJ, Yoon J, Misch CE, Wang HL.The causes of early implant bone loss: myth or science? J Periodontol 2002; 73: 322-33.

Quirynen M, Bollen CM.The influence of surface roughness and surface-free energy on supra- and subgingival plaque formation in man. A review of the literature. J Clin Periodontol 1995; 22: 1-14.

Quirynen M, Bollen CM, Papaioannou W, Van Eldere J, van Steenberghe D. The influence of titanium abutment surface roughness on plaque accumulation and gingivitis: short-term observations. Int J Oral Maxillofac Implants 1996; 11: 169-78.

Sumida S, Ishihara K, Kishi M, Okuda K. Transmission of periodontal disease-associated bacteria from teeth to osseointegrated implant regions. Int J Oral Maxillofac Implants 2002; 17: 696-702.

Quirynen M, Peeters W, Naert I, Coucke W, van Steenberghe D. Peri-implant health around screw-shaped c.p. titanium machined implants in partially edentulous patients with or without ongoing periodontitis. Clin Oral Implants Res 2001; 12: 589-94.

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