Genes and tooth development: reviewing the structure and function of some key players.


  • Raquel Mantuaneli S. Caminaga University of the Sacred Heart
  • Silvana Pasetto Department of Morphology, Piracicaba/Dental School
  • E. Ribeiro da Silva Department of Morphology, Piracicaba
  • Regina Célia Rocha Peres Department of Morphology, Piracicaba Dental School, State University of Campinas



Tooth morphogenesis. Genes. Molecular signaling


Similar to many other embryonic organs, the mammalian tooth development relies largely on epithelial-mesenchymal interactions. Tooth development may be divided in multiple stages, where the number, size and type of teeth are sequentially determined. Teeth are serially homologous structures, which allow the localization and quantification of the effects of specific gene mutations. Furthermore, it is also possible to determine the phase of odontogenesis affected by these conditions. These features make anomalies involving teeth an important system to understand the intricate molecular mechanisms that regulate developmental process. In this paper we review the structure and function of some key molecules that participate in tooth development.


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Author Biographies

Raquel Mantuaneli S. Caminaga, University of the Sacred Heart

Possui graduação em Ciências Biológicas pela Universidade Estadual de Campinas (1997), Mestrado em Biologia Patologia Buco-Dental pela Universidade Estadual de Campinas (2000), Doutorado em Biologia Buco-Dental pela Universidade Estadual de Campinas (2002) e Pós-Doutorado em Mutagênese pela Faculdade de Medicina de Ribeirão Preto, FMRP-USP (2010). Atua como Professor Adjunto da Universidade Estadual Paulista Júlio de Mesquita Filho - Faculdade de Odontologia de Araraquara, sendo responsável pela Disciplina de Genética Humana. Orienta acadêmicos de Graduação, Mestrado, Doutorado e Pós-Doutorado.

Silvana Pasetto, Department of Morphology, Piracicaba/Dental School

Possui graduação em Ciências Biológicas - pelo Centro Universitário Herminio Ometto, especialização em Tecnologia de Alimentos pela Universidade Metodista de Piracicaba, mestrado em Biologia e Patologia Buco-Dental - área de concentração em Morfologia pela UNICAMP - Universidade Estadual de Campinas (2000) e doutorado em Biologia Buco-Dental - área de concentração em Morfologia pela Universidade Estadual de Campinas (2005). Tem experiência na área de Biologia/Morfologia, com ênfase em histologia e embriologia.

Regina Célia Rocha Peres, Department of Morphology, Piracicaba Dental School, State University of Campinas

Possui graduação em Odontologia pela Universidade Federal de Sergipe (1993), Especialização em Odontopediatria e Ortopedia Funcional dos Maxilares, Mestrado em Odontologia-Área de Farmacologia e Terapêutica Medicamentosa (2000) e Doutorado em Biologia Patologia Buco-Dental pela FOP/UNICAMP (2004). Atualmente é professor colaborador na área de Odontopediatria da Faculdade de Odontologia de Piracicaba/UNICAMP.


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How to Cite

Caminaga RMS, Pasetto S, Silva ER da, Peres RCR. Genes and tooth development: reviewing the structure and function of some key players. Braz. J. Oral Sci. [Internet]. 2015 Nov. 12 [cited 2022 Dec. 1];2(7):339-47. Available from:



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