Oral melanoma: review of the literature

Authors

  • Aline Mie Uratani Department of Oral Diagnosis, Dental School, University of Campinas.
  • Danyel Elias da Cruz Perez Department of Oral Diagnosis, Dental School, University of Campinas.
  • Pablo Agustin Vargas Department of Oral Diagnosis, Dental School, University of Campinas.
  • Jacks Jorge Júnior Department of Oral Diagnosis, Dental School, University of Campinas
  • Márcio Ajudarte Lopes Department of Oral Diagnosis, Dental School, University of Campinas.

DOI:

https://doi.org/10.20396/bjos.v3i9.8641741

Keywords:

Oral melanoma. Review

Abstract

Oral melanoma (OM) is an uncommon malignant tumor originated from the proliferation of melanocytes cells. This tumor can be present at any location in the oral cavity, however, it affects more frequently the hard palate and the maxillary alveolar mucosa. There seem to have a predilection for males, elderly and Japanese people. OM is usually asymptomatic in the early stages and it presents normally as a pigmented patch or mass with a rapid growth rate. In advanced stages, can show ulceration, swelling, bleeding, rapid enlargement and loosening of teeth. Diagnosis is based on the histological features, which are characterized by atypical melanocytes initially at the epithelialconnective tissue junction and later, invading the subepithelial connective tissue. The treatment of choice is a radical surgical excision. Additional treatments such as radiotherapy and chemotherapy have also been used to improve the prognosis. The main complications are the metastasis which can occur to any organ with a predilection for the cervical lymph nodes. The prognosis is extremely poor especially in advanced stages.

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Author Biographies

Danyel Elias da Cruz Perez, Department of Oral Diagnosis, Dental School, University of Campinas.

Graduate at Odontologia from Universidade Federal de Uberlândia (2000), master's at Odontology from Universidade Estadual de Campinas (2002) and ph.d. at Odontology from Universidade Estadual de Campinas (2005). Has experience in Odontology, acting on the following subjects: mucosa bucal, mucoepidermoid carcinoma, glândulas salivares, carcinoma mucoepidermóide and adenoid cystic carcinoma.

Pablo Agustin Vargas, Department of Oral Diagnosis, Dental School, University of Campinas.

Dr Vargas is a dental graduate of the UNESP-Araraquara-Brazil and obtained a Master of Science and PhD titles from the UNICAMP-Piracicaba-Brazil in Oral Pathology. He was chairman of the post-graduate course of Oral Pathology-UNICAMP for 4 years (2000-2004). He was also president of the II International Congress of Dentistry of the UNICAMP, which was held in Piracicaba, Brazil in 2004. He was Honorary Senior Lecturer of the Department of Oral Pathology of the University of Sheffield-UK (2005-2007). He has been teaching Oral Pathology in the School of Dentistry of Piracicaba-UNICAMP. He was vice-chair of the Department of Oral Diagnosis-UNICAMP and Latin America and Caribbean Councillor of the International Association of Oral Pathologists (IAOP) (2008-2012). He was local president of the XVI International Congress of Oral Pathology and Medicine (IAOP-SOBEP Joint Meeting), which was held in São Pedro, Brazil in 2012. He has authored or co-authored 1 chapter and 164 papers (134 indexed in PUBMED) on Oral Pathology and Medicine. He has been acting as reviewer of numerous international periodicals as Oral Oncology, Oral Diseases, Indian Journal of Cancer, Yonsei Medical Journal and Medicinal Oral Patologia Oral Cirurgia Oral. He belongs to the editorial board of 2 international journals: 1- Oral Oncology; 2- Oral Surg Oral Med Oral Path Oral Radiol. He was granted with FRCPath (The Royal College of Pathologists-UK) in January-2013 and Extraordinary Professor at University of Pretoria-South Africa. He is a diagnostic pathologist of oral lesions in Piracicaba and his main research fields are molecular pathology of salivary gland lesions, cysts and odontogenic tumours, and salivary gland involvement in AIDS patients.

Jacks Jorge Júnior, Department of Oral Diagnosis, Dental School, University of Campinas

Graduate at Odontologia from Faculdade de Odontologia João Prudente (1983), master's at Odontology from Universidade Estadual de Campinas (1990) and ph.d. at Odontology from Universidade Estadual de Campinas (1996). Has experience in Odontology, acting on the following subjects: Oral carcinogênesis, bone repair, candidosis, elderly and oral lesions.

Márcio Ajudarte Lopes, Department of Oral Diagnosis, Dental School, University of Campinas.

Has graduation at Odontologia by Universidade Estadual de Campinas (1990) , master's at Biologia Patologia Buco Dental by Universidade Estadual de Campinas (1993) , Ph.D. at Biologia Patologia Buco Dental by Universidade Estadual de Campinas (1996) and Postdoctorate by University Of Maryland At Baltimore (2000) . Currently is of Universidade Estadual de Campinas, Revisor de periódico of International Journal of Oral and Maxillofacial Surgery, Revisor de periódico of Human Pathology, Revisor de periódico of Oral Oncology, Revisor de periódico of Brazilian Journal of Oral Sciences, Revisor de periódico of Journal of Applied Oral Science (1678-7757), Revisor de periódico of RGO. Revista Gaúcha de Odontologia, Revisor de periódico of Cytopathology (Oxford), Revisor de periódico of Brazilian Dental Journal, Revisor de periódico of Oral Surgery, Membro de corpo editorial of SRX Dentistry, Revisor de periódico of Journal of Zhejiang University science b, Revisor de periódico of Archives of Oral Biology, Revisor de periódico of European Journal of Dentistry, Revisor de periódico of Medicina oral, patología oral y cirugía bucal (Internet), Revisor de periódico of Clinics (USP. Impresso), Membro de corpo editorial of Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics, Membro de corpo editorial of International Journal of Case Reports in Medicine, Membro de corpo editorial of World Journal of Clinical Cases, Membro de corpo editorial of American Journal of Oral Medicine, Membro de corpo editorial of Medicina Oral Patologia Oral y Cirugia Bucal e Membro de corpo editorial of International Journal of Oral and Maxillofacial Pathology. Has experience in the area of Odontology , with emphasis on Semiologia. 

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Published

2015-11-16

How to Cite

1.
Uratani AM, Perez DE da C, Vargas PA, Jorge Júnior J, Lopes MA. Oral melanoma: review of the literature. Braz. J. Oral Sci. [Internet]. 2015 Nov. 16 [cited 2022 Nov. 26];3(9):428-32. Available from: https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8641741

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