Response of human dental pulp to calcium hydroxide paste preceded by a corticosteroid/ antibiotic dressing agent

Authors

  • Elisa Maria Aparecida Giro Universidade Estadual Paulista - UNESP
  • Juliana Oliveira Gondim Universidade Estadual Paulista - UNESP, Araraquara, SP
  • Josimeri Hebling Universidade Estadual Paulista - UNESP, Araraquara, SP
  • Carlos Alberto de Souza Costa Universidade Estadual Paulista - UNESP, Araraquara, SP.

DOI:

https://doi.org/10.20396/bjos.v9i3.8641773

Keywords:

Calcium hydroxide, Corticosteroid, Dental pulp capping, Permanent dentition, Pulpotomy

Abstract

Aim: To evaluate the treatment with corticosteroid/antibiotic dressing in pulpotomy with calcium hydroxide. Methods: Forty-six premolars were pulpotomized and randomly assigned into 3 groups. In Group I pulpal wound was directly capped with calcium hydroxide, and Group II and Group III received corticosteroid/antibiotic dressing for 10 min or 48 h, respectively, before pulp capping. Teeth were processed for histological analysis after 7, 30 or 60 days to determine inflammatory cell response, tissue disorganization, dentin bridge formation and presence of bacteria. Attributed scores were analyzed by Kruskal-Wallis and Mann-Whitney tests (α=0.05). Results: On the 7th day, all groups exhibited dilated and congested blood vessels in the tissue adjacent to pulpal wound. The inflammatory cell response was significantly greater in Group III (p<0.05). On the 30th day, in all groups, a thin dentin matrix layer was deposited adjacent to the pulpal wound and a continuous odontoblast-like cell layer underlying the dentin matrix was observed. On the 60th day, all groups presented a thick hard barrier characterized by an outer zone of dystrophic calcification and an inner zone of tubular dentin matrix underlined by a defined odontoblast-like cell layer. Conclusions: Within the limitations of present study, considering that the treatment was performed in healthy teeth, it may be concluded that the use of a corticosteroid/antibiotic dressing before remaining tissue protection with calcium hydroxide had no influence on pulp tissue healing

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Author Biographies

Elisa Maria Aparecida Giro, Universidade Estadual Paulista - UNESP

DDS, MSc, PhD, Professor, Department of Orthodontics and Pediatric Dentistry, School of Dentistry of Araraquara, Universidade Estadual Paulista - UNESP, Araraquara, SP

Juliana Oliveira Gondim, Universidade Estadual Paulista - UNESP, Araraquara, SP

DDS, MSc, Assistant Professor, Department of Dentistry, School of Dentistry, Federal University of Ceará, Sobral, Fortaleza, CE, Brazil; Graduate Student, Department of Orthodontics and Pediatric Dentistry, School of Dentistry of Araraquara, Universidade Estadual Paulista - UNESP, Araraquara, SP

Josimeri Hebling, Universidade Estadual Paulista - UNESP, Araraquara, SP

DDS, MSc, PhD, Professor, Department of Orthodontics and Pediatric Dentistry, School of Dentistry of Araraquara, Universidade Estadual Paulista - UNESP, Araraquara, SP

Carlos Alberto de Souza Costa, Universidade Estadual Paulista - UNESP, Araraquara, SP.

DDS, MSc, PhD, Professor, Department of Physiology and Pathology, School of Dentistry of Araraquara, Universidade Estadual Paulista - UNESP, Araraquara, SP.

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Published

2015-11-18

How to Cite

1.
Giro EMA, Gondim JO, Hebling J, Costa CA de S. Response of human dental pulp to calcium hydroxide paste preceded by a corticosteroid/ antibiotic dressing agent. Braz. J. Oral Sci. [Internet]. 2015Nov.18 [cited 2020Nov.26];9(3):337-44. Available from: https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8641773

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