Analgesic choice in dentistry Part II : The toxicity

Authors

  • Marcos Luciano Pimenta Pinheiro University of Vale do Jequitinhonha and Mucuri
  • Filipe Polese Branco Piracicaba Dental School, Campinas State University
  • Maria Cristina Volpato Piracicaba Dental School, Campinas State University
  • Eduardo Dias Andrade Piracicaba Dental School, Campinas State University, Piracicaba

DOI:

https://doi.org/10.20396/bjos.v4i15.8641849

Keywords:

Analgesics. Toxicity. Dentistry

Abstract

Nonopioid analgesics are widely prescribed in dentistry. The first article of this series reviewed the mechanism of action of acetylsalicylic acid (aspirin), acetaminophen (paracetamol) and dipyrone; this part discusses the risks related to the use of these drugs. Paracetamol and dipyrone in therapeutic doses, unlike aspirin, do not cause nausea, do not interfere with protrombin time, do not inhibit the platelet aggregation, and do not produce as many side effects as does aspirin. The adverse reactions in relation to paracetamol seem to be restricted to situations where acute overdosage occurs. In relation to dipyrone, blood dyscrasias such as the agranulocytosis are the main adverse reactions.

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Author Biographies

Marcos Luciano Pimenta Pinheiro, University of Vale do Jequitinhonha and Mucuri

Possui graduação em Farmácia-Bioquímica pela Universidade Federal de Ouro Preto (1993), mestrado em Odontologia pela Faculdade de Odontologia de Piracicaba (2003) e doutorado em Odontologia pela Faculdade de Odontologia de Piracicaba (2005).

Filipe Polese Branco, Piracicaba Dental School, Campinas State University

Doutor em Odontologia pela UNICAMP (2008) Mestre em Farmacologia, Anestesiologia e Terapêutica pela UNICAMP (2003) Especialista em Implantodontia (2014) Habilitação Sedação Consciente com Óxido Nitroso (2005) Graduado em Odontologia pela Universidade do Vale do Itajaí (2001) Professor de Farmacologia, Anestesiologia e Cirurgia na Faculdade Avantis - Balneário Camboriú Diretor do Instituto de Pós graduação e Pesquise em Odontologia - Instituto IPPO - Balneário Camboriú 

Maria Cristina Volpato, Piracicaba Dental School, Campinas State University

has graduation at Odontologia by Universidade Estadual de Campinas (1985) , master's at Odontologia by Universidade Estadual de Campinas (1991) and Ph.D. at Odontologia by Universidade Estadual de Campinas (1995) . Currently is professor of Universidade Estadual de Campinas, Revisor de periódico of Revista de Odontologia da UNESP, Revisor de periódico of Journal of Applied Oral Science, Revisor de periódico of RPG. Revista de Pós-Graduação (USP), Membro de corpo editorial of Brazilian Journal of Oral Sciences (Online), Membro de corpo editorial of Brazilian Journal of Oral Sciences (Impresso), Membro de comitê assessor of Conselho Nacional de Desenvolvimento Científico e Tecnológico, Revisor de projeto de fomento of Fundação de Amparo à Pesquisa do Estado de São Paulo, Revisor de periódico of RGO. Revista Gaúcha de Odontologia (Online), Revisor de periódico of Brazilian oral research e Revisor de periódico of Brazilian Journal of Oral Sciences (Online). Has experience in the area of Odontology , with emphasis on Anestesiologia. Focused, mainly, in the subjects: anestesia pulpar, bupivacaína, levobupivacaína. 

Eduardo Dias Andrade, Piracicaba Dental School, Campinas State University, Piracicaba

has graduation at Faculdade de Odontologia de Piracicaba by Universidade Estadual de Campinas (1970) , master's at Odontologia by Universidade Estadual de Campinas (1980) and Ph.D. at Odontologia by Universidade Estadual de Campinas (1985) . Currently is Servidor público ou celetista of Universidade Estadual de Campinas. Has experience in the area of Odontology , with emphasis on Farmacologia. Focused, mainly, in the subjects: Inflamação, Diapedese, Dipirona, Betametasona. 

References

Alonzo HGA, Corrêa CL, Zambrone FAD. Analgésicos, antipiréticos e antiinflamatórios não esteroidais: dados epidemiológicos em seis centros de controle de intoxicações no Brasil. Rev Bras Toxicol. 2001; 14: 49-54.

Katzung BG, Trevor AJ. Nonsteridal anti-inflamatory drugs, nonopioid analgesics, e drugs used in gout. pharmacology. examination & board review. 3rd ed. East Norwalk: Appleton & Lange; 1993.

Vane JR, Botting RM. New insights into the mode of action of anti-inflammatory drugs. Inflamm Res. 1995; 44: 1-10.

Cooper AS, Desjardins PJ. Peripherally acting (nonopioid) analgesics. In: Neidle EA, Yagiela JA. Pharmacology and therapeutics for dentistry. 3rd ed. Saint Lowis: Mosby; 1989. p.293-307.

Yagiela JA, Neidle EA, Dowd FJ. Farmacologia e terapêutica para dentistas.4. ed. Guanabara Koogan: Rio de Janeiro; 2000.

Bobbio A, Bobbio SA. Indicações e limites da prescrição na gravidez. Rev Paul Odontol. 1979; 1: 10-9.

Delzer DD, Provant-Jr DD. Pregnancy and size effects of analgesics. Gen Dent. 1981; 29Wormald DL. Drogas y embarazo. Rev Chil Obstet Ginecol. 1991; 56: 293-300.

Miller MC. The pregnant dental patient. J Calif Dent Assoc. 1995; 23: 63-70.

Insel PA. Analgesic-antipyretic and anti-inflammatory agents and drugs employed in the treatment of gout. In: Goodman and Gilman’s the pharmacological basis of therapeutics. 9th ed. New York: Mc Graw Hill; 1996. p.617-57.

Grattan CE. Aspirin sensitivity and urticaria. Clin Exp Dermatol. 2003; 28: 123-7.

Sullivan-Bolyai JZ, Corey L. Epidemiology of Reye’s Syndrome. Epidemiol Rev. 1981; 3: 1-26.

Lane JE, Belson MG, Brown DK, Scheetz A. Chronic acetaminophen toxicity: a care report review of the literature. J Emerg Med. 2002; 23: 253-6.

Smilkstein MJ, Knapp Gl, Kulig KW, Rumack BH. Efficacy of oral N-acetilcysteine in the treatment of acetaminophen overdose. Analyses of the national multicenter study (1976 to 1985). N Engl J Med. 1988; 319: 1557-62.

Payan DG, Katzung BG. Nonsteroidal anti-inflammatory drugs; Nonopioid analgesics; Drugs used in gout. In: Katzung BG. Basic & clinical pharmacology. 6th ed. East Norwalk: Appleton & Lange; 1995. p.552.

Grahan GG, Scott KF, Day RO. Tolerability of paracetamol. Drugs. 2003; 63: 43-6. Thomas SH. Paracetamol (acetaminophen) poisoning. Pharmacol Ther. 1993; 60: 91-120.

Lüllmann H, Mohr K. Farmacologia – texto e atlas. 4. ed. Artmed : Porto Alegre; 200Perusse R, Goulet JP, Turcotte JY: Contraindications to vasoconstrictors in dentistry: Part II. Oral Surg Oral Med Oral Pathol. 1992; 74: 687-91.

Perusse R, Goulet JP, Turcotte JY: Contraindications to vasoconstrictors in dentistry: Part II. Oral Surg Oral Med Oral Pathol. 1992; 74: 687-91.

Bar-Oz B, Clementi M, Giantonio E, Greenberg R, Beer M, Merlob P, et al. Metamizol (dypirone, optalgin) in pregnancy, is it safe? A prospective study. Eur J Obstet Gynecol Reprod Biol. 2005; 119: 176-9.

Benseñor IM. To use or not to use dipyrone? Or maybe, central station versus ER? That is the question. São Paulo Med J 2001; 119: 190-1.

Hedenmalm K, Spigset O. Agranulocytosis and other blood dyscrasias associated with dipyrone (metamizole). Eur J Clin Pharmacol. 2002; 58: 265-74.

Andrade SE. Comparative safety evaluation of non-narcotic analgesics. J Clin Epidemiol. 1998; 51: 1357-65.

International Agranulocytosis and Aplastic Anemia Study (The Boston Study). Risks of agranulocytosis and aplastic anemia. A first report of their relation to drug use with reference to analgesics. J Am Med Assoc. 1986; 256: 1749-57.

Ibanez L, Vidal X, Ballarin E, Laporte JR. Agranulocytosis associated with dipyrone (metamizol). Eur J Clin Pharmacol. 2005; 60: 821-9.

Painel internacional de avaliação da segurança da dipirona. 2001 Jul 3-4; Brasília; 2001.Disponível em: http://www.anvisa.gov.br/ divulga/alertas.

Szczklik A. Analgesics, allergy and asthma. Drugs. 1986; 32: 148-63.

Levy S, Volans G. The use of analgesics in patients with asthma. Drug Saf. 2001; 24: 829-41.

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Published

2015-11-19

How to Cite

1.
Pinheiro MLP, Branco FP, Volpato MC, Andrade ED. Analgesic choice in dentistry Part II : The toxicity. Braz. J. Oral Sci. [Internet]. 2015 Nov. 19 [cited 2022 Nov. 26];4(15):880-3. Available from: https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8641849

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Literature Reviews

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