Matrix metalloproteinases: the most important pathway involved with periodontal destruction

Authors

  • A.P De Souza Piracicaba Dental School/University of Campinas
  • R.A Da Silva Piracicaba Dental School/University of Campinas
  • M.A.D Da Silva Piracicaba Dental School/University of Campinas
  • Sérgio Augusto Catanzaro Guimarães PRPPG/University of Sagrado Coração
  • Sergio Roberto Peres Line Piracicaba Dental School/University of Campinas

DOI:

https://doi.org/10.20396/bjos.v4i15.8641850

Keywords:

MMP. Cytokine. Periodontitis. Genes polymorphisms

Abstract

Periodontitis is an infectious disease estimated to occur in approximately a third of adults over the age of 35, being the major cause of adult tooth loss. The tissue destruction seems to be regulated by four major pathways. Plasminogen-dependent, phagocytic, osteoclastic and matrix metalloproteinase pathway. The matrix metalloproteinases (MMPs) pathway seems to be the most relevant in periodontal disease. The purpose of the current study was to review the roles of MMPs on periodontal disease, with emphasis on periodontal ligament and alveolar bone destruction. Particular attention is given on the mechanisms that control MMPs genes transcription, the regulation of protein activity, and the influence of MMP genes polymorphisms in inflammatory diseases.

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Author Biographies

Sérgio Augusto Catanzaro Guimarães, PRPPG/University of Sagrado Coração

Possui graduação em Odontologia pela Faculdade de Odontologia de Araraquara(1961), especialização em Patologia Bucal e Geral pela Sociedade Brasileira de Patologia(1975), doutorado em Patologia pela Universidade de São Paulo(1967) e pós-doutorado pela Temple University School Of Medicine Usa(1972).

Sergio Roberto Peres Line, Piracicaba Dental School/University of Campinas

has graduation at Odontologia by Universidade Estadual de Campinas (1985) , Ph.D. at Patologia Experimental e Comparada by Universidade de São Paulo (1989) and Postdoctorate by National Institute Of Health (1991) . Currently is Servidor público ou celetista of Universidade Estadual de Campinas, Membro de corpo editorial of Journal of Applied Oral Science (Impresso), Membro de corpo editorial of Brazilian Journal of Oral Sciences (Impresso) e of Faculdade de Odontologia de Piracicaba-UNICAMP. Has experience in the area of Odontology. Focused, mainly, in the subjects: Laminina, Matriz extracelular, Menbrana Basal, Metaloproteases. 

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Published

2015-11-19

How to Cite

1.
De Souza A, Da Silva R, Da Silva M, Guimarães SAC, Line SRP. Matrix metalloproteinases: the most important pathway involved with periodontal destruction. Braz. J. Oral Sci. [Internet]. 2015 Nov. 19 [cited 2022 Nov. 28];4(15):884-90. Available from: https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8641850

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