Prevalence of TT Virus in patients with chronic periodontitis, patients with aggressive periodontitis and healthy controls - a pilot study

Authors

  • Gurumoorthy Kaarthikeyan Saveetha Dental College and hospitals
  • N. D. Jayakumar Saveetha Dental College and hospitals
  • Ogoti Padmalatha aveetha Dental College and hospitals
  • Sheeja Varghese Saveetha Dental College and hospitals
  • Khalefathullah Sheriff

DOI:

https://doi.org/10.20396/bjos.v9i2.8641863

Keywords:

Clinical attachment level, Periodontitis, Pocket depth, Polymerase chain reaction. Torque teno virus

Abstract

Torque teno virus (TTV), a novel DNA virus resides in peripheral blood mononuclear cells and replicates when these cells get activated. The TTV replication shifts the immunobalance. Aim: To determine the presence of TTV in the gingiva of patients with aggressive periodontitis, patients with chronic periodontitis, and healthy controls, and to correlate the presence of TTV with probing pocket depth and clinical attachment level. Methods: Forty-two subjects (22 males and 20 females) aged 21 to 55 years were recruited for this study. Subjects were stratified into aggressive periodontitis (Group I), chronic periodontitis (Group II) and healthy controls (Group III). Gingival tissue biopsy was taken from all the subjects and the presence of TTV was analyzed using PCR and 2% agarose gel electrophoresis. Results: TTV was identified in half of the subjects and more number of subjects with periodontitis have TT virus compared to controls. There was significant association between presence of TT virus and pocket depth, clinical attachment level. Conclusions: The findings from the present study shows that there was no significant association between TT virus and periodontitis, even though it was isolated from more number of subjects with aggressive periodontitis, and TTV was associated with pocket depth and clinical attachment level. These findings need to be investigated in further studies.

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Author Biographies

Gurumoorthy Kaarthikeyan, Saveetha Dental College and hospitals

MDS, Senior lecturer, department of Periodontics, Saveetha Dental College and hospitals, Chennai

N. D. Jayakumar, Saveetha Dental College and hospitals

MDS, Principal and H.O.D, Department of Periodontics, Saveetha Dental College and hospitals

Ogoti Padmalatha, aveetha Dental College and hospitals

MDS, Professor, Department of Periodontics, Saveetha Dental College and hospitals, Chenna

Sheeja Varghese, Saveetha Dental College and hospitals

MDS, Professor, Department of Periodontics, Saveetha Dental College and hospitals, Chenna

Khalefathullah Sheriff

PhD, Department of Virology , King Institute, Chennai

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Published

2015-11-25

How to Cite

1.
Kaarthikeyan G, Jayakumar ND, Padmalatha O, Varghese S, Sheriff K. Prevalence of TT Virus in patients with chronic periodontitis, patients with aggressive periodontitis and healthy controls - a pilot study. Braz. J. Oral Sci. [Internet]. 2015 Nov. 25 [cited 2022 Nov. 26];9(2):94-7. Available from: https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8641863

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