Candida albicans proteinases

Authors

  • Rita de Cássia Mardegan University of Campinas/Piracicaba Dental School
  • Mary Ann Foglio Department of Phytochemical, University of Campinas
  • Reginaldo Bruno Gonçalves University of Campinas - Piracicaba Dental School
  • José Francisco Höfling University of Campinas - Piracicaba Dental School

DOI:

https://doi.org/10.20396/bjos.v5i16.8641872

Keywords:

Proteinases. Virulence. Candida

Abstract

Candida species are ubiquitous commensal yeast that usually reside as part of an individual´s normal mucosal microflora and can be detected in approximately 50% of the population in this form. However, if the balance of the normal flora is disrupted or the immune defences are compromised, Candida species can invade mucosal surfaces and cause disease manifestations. Determining exactly how this transformation from commensal to pathogen takes place and how it can be prevented is a continuing challenger for the medical mycology field. Attributes that contribute to Candida albicans virulence include adhesion, hyphal formation, phenotypic switching and extra cellular hydrolytic enzyme production. The extra cellular hydrolytic enzyme, especially the secreted aspartyl proteinases (Saps), are one a few gene products that have been shown to directly contribute to C. albicans pathogenicity. Given the limited number of suitable and effective antifungal drugs, the continuing increase in the incidence of Candida infections, together with increasing drug resistance, highlights the need to discover new and better agents that target fundamental biological processes and or pathogenic determinants of C. albicans.

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Author Biographies

Rita de Cássia Mardegan, University of Campinas/Piracicaba Dental School

Has graduation at Biologia by Universidade Metodista de Piracicaba (1994) , specialization at Ciencia e Tecnologia de Alimentos by Universidade Metodista de Piracicaba (1995) , master's at Biologia Patologia Buco Dental by Universidade Estadual de Campinas (2003) , Ph.D. at Biologia e Patologia Buco Dental by Faculdade de Odontologia de Piracicaba (UNICAMP) (2007) , ensino-fundamental-primeiro-grau by EE1ª e 2ª graus Prof. João Batista Nogueira (1996) , ensino-medio-segundo-grau by Colégio Piracicabano (1988) and ensino-medio-segundo-grau by Colégio Salesiano Dom Bosco (1989) . Has experience in the area of General Biology. Focused, mainly, in the subjects: Candida spp, Plantas Medicinais, proteinase.

Mary Ann Foglio, Department of Phytochemical, University of Campinas

Has graduation at Quimica by Universidade Estadual de Campinas (1982) , master's at Química by Universidade Estadual de Campinas (1987) , Ph.D. at Química by Universidade Estadual de Campinas (1996) and Postdoctorate by Technische Universitat Braunschweig (1998) . Currently is professor of Universidade Estadual de Campinas, Revisor de periódico of Química Nova, Revisor de periódico of Brazilian Journal of Microbiology, Revisor de periódico of Journal of the Brazilian Chemical Society, Revisor de periódico of Bioorganic and Medicinal Chemistry Letters, Revisor de periódico of Journal of Pharmacy and Pharmacology, Revisor de periódico of Planta Medica (Stuttgart), Membro de corpo editorial of Revista Fitos (ALANAC) e of faculdade de ciencias farmaceutica. Has experience in the area of Pharmacy , with emphasis on Farmacognosia. Focused, mainly, in the subjects: Artemisia annua L., Arrabidaea chica Verlot., Pterodon pubescens Benth, atividade anticancer, atividade antinociceptiva e atividade antimalarica. 

Reginaldo Bruno Gonçalves, University of Campinas - Piracicaba Dental School

Professor Titular de microbiologia e imunologia da Faculdade de Odontologia da Universidade Estadual de Campinas e professor associado em Periodontia da Faculté de Medecine Dentaire, Université Laval, Québec, Canada. Possui graduação em Odontologia pela Universidade Estadual de Campinas (1987), especialização em Endodontia pela FOP-Unicamp (1989), mestrado em Biologia Patologia Buco-Dental pela Universidade Estadual de Campinas (1994) e doutorado em Ciências (Microbiologia) pela Universidade Federal do Rio de Janeiro com estagio no GREB-Universite Laval, Quebec, Canada (1998). Tem pós doutorado pelo Instituto Forsyth, Boston, EUA (2002-2005). 

José Francisco Höfling, University of Campinas - Piracicaba Dental School

Graduate at História Natural das Ciências from Universidade Estadual Paulista Júlio de Mesquita Filho (1970), master's at Immunology from Universidade Estadual de Campinas (1974) and ph.d. at Immunology from Universidade Estadual de Campinas (1975). Has experience in Microbiology, focusing on Medical Microbiology, acting on the following subjects: streptococcus mutans, candida albicans, sds-page, crianças and streptococcus sobrinus.

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Published

2015-11-16

How to Cite

1.
Mardegan R de C, Foglio MA, Gonçalves RB, Höfling JF. Candida albicans proteinases. Braz. J. Oral Sci. [Internet]. 2015 Nov. 16 [cited 2022 Aug. 18];5(16):944-52. Available from: https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8641872

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