The role of metronidazole on the establishment and persistence of oral candidosis

Authors

  • Veronica Quispe Yujra São Paulo State University
  • Alexandre Prado Scherma São Paulo State University
  • Juliana Campos Junqueira School of Dentistry of São José dos Campos, São Paulo State University
  • Antônio Olavo Cardoso Jorge School of Dentistry of São José dos Campos, São Paulo State University
  • Rosilene Fernandes Rocha School of Dentistry of São José dos Campos, São Paulo State University

DOI:

https://doi.org/10.20396/bjos.v5i17.8641894

Keywords:

Candida albicans. Candidosis. Metronidazole. Rats

Abstract

The aim of this study was to study the effects of metronidazole on the establishment of oral candidosis and Candida albicans colonization in the oral cavity of rats. Forty-eight male rats, negative for yeasts in the oral cavity, were used in the study. The rats were inoculated with a suspension of Candida albicans and treated with metronidazole or plain water (control group). The rats of the candidosis experimental group were sacrificed 7, 15, or 30 days after inoculation and their tongues were analyzed by light microscopy. Colonization by Candida albicans was evaluated 1, 2, 5 and 7 days after inoculation and progressively at 15-day intervals, with a total of 18 collections. The results demonstrated the development of candidosis on the tongue dorsum was similar between the Control and Metronidazole groups for each sacrifice period. However, the colonization results showed that yeasts were recovered in the Metronidazole group in greater numbers than in the Control group after the 37th day of the experiment (6th collection). According this, the long term metronidazole therapy favored the colonization of C. albicans in the oral cavity of rats.

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Author Biographies

Veronica Quispe Yujra, São Paulo State University

Operates on the following topics: Experimental pathology, alcohol diet, osteopenia, rats. Management of health services.

Alexandre Prado Scherma, São Paulo State University

graduate at Odontologia from Universidade de Taubaté (1995), master's at Biopatologia Bucal from Universidade Estadual Paulista Júlio de Mesquita Filho (2002) and ph.d. at Biopatologia Bucal from Universidade Estadual Paulista Júlio de Mesquita Filho (2005). Has experience in Odontology, acting on the following subjects: candida albicans, candidose bucal, cárie, candida and prevenção.

Juliana Campos Junqueira, School of Dentistry of São José dos Campos, São Paulo State University

Professora Adjunto de Microbiologia e Imunologia do curso de Odontologia do Instituto de Ciência e Tecnologia ICT/UNESP-São José dos Campos e Coordenadora do Programa de Pós-graduação em Biopatologia Bucal. Possui graduação em Odontologia pela Universidade Estadual Paulista Júlio de Mesquita Filho (1998), mestrado em Biopatologia Bucal pela Universidade Estadual Paulista Júlio de Mesquita Filho (2001), doutorado em Biopatologia Bucal pela Universidade Estadual Paulista Júlio de Mesquita Filho (2003) e livre-docência em Microbiologia e Imunologia pela Universidade Estadual Paulista Júlio de Mesquita Filho (2011).

Antônio Olavo Cardoso Jorge, School of Dentistry of São José dos Campos, São Paulo State University

Possui graduação em Odontologia pela Universidade Estadual Paulista Júlio de Mesquita Filho (1977), Especialização em Biologia e em Endodontia, Mestrado em Biologia (Fisiopatologia Celular) pela Universidade de Taubaté (1986), mestrado em Biologia Patologia Buco-Dental pela Universidade Estadual de Campinas (1988), Doutorado em Biologia Patologia Buco-Dental pela Universidade Estadual de Campinas (1991) e Livre-Docência em Microbiologia e Imunologia pela Faculdade de Odontologia de São José dos Campos/UNESP (1995).

Rosilene Fernandes Rocha, School of Dentistry of São José dos Campos, São Paulo State University

Possui graduação em Ciências Biológicas Modalidade Médica pela Faculdade de Filosofia Ciências e Letras Barão de Mauá de Ribeirão Preto (1976). Mestrado em Farmacologia pela Escola Paulista de Medicina (1983) e doutorado em Farmacologia pela Faculdade de Odontologia de Piracicaba Unicamp (1990).

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Published

2015-11-25

How to Cite

1.
Yujra VQ, Scherma AP, Junqueira JC, Jorge AOC, Rocha RF. The role of metronidazole on the establishment and persistence of oral candidosis. Braz. J. Oral Sci. [Internet]. 2015 Nov. 25 [cited 2023 Jan. 30];5(17):1041-7. Available from: https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8641894

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