Inflammatory cytokines activity in temporomandibular joint disorders: a review of literature

Authors

  • Maria Isabela Guimarães Campos State University of Campinas
  • Paulo Sérgio Flores Campos Federal University of Bahia
  • Sergio Roberto Peres Line State University of Campinas

DOI:

https://doi.org/10.20396/bjos.v5i18.8641896

Keywords:

TMJ. Temporomandibular joint disorders. Osteoarthritis. Cytokines. Interleukins

Abstract

Cytokines are important polypeptides mediators of acute and chronic inflammation. These molecules act as a complex immunological network, in which there are pro-inflammatory cytokines, such as interleukin-1 (IL-1), IL-6 and tumor necrosis factor-a (TNF-a), and anti-inflammatory mediators like IL-10 and transforming growth factor-b. In spite of some controversial findings, in general high levels of pro-inflammatory cytokines have been correlated with signs and symptoms of temporomandibular disorders (TMD) such as internal derangement and osteoarthritis. These mediators promote degradation of cartilage and bone joint by inducing release of proteinases and other inflammatory molecules. Indeed, pro-inflammatory cytokines have been associated with temporomandibular joint (TMJ) tissue destruction. However, its mechanisms and pathophysiology have not been clearly delineated. In attempt to summarize the role of cytokines in TMD pathophysiology and its potential for medical intervention, the purpose of the current study was to review the literature concerning the analysis of these inflammatory mediators in TMJ fluid and tissues.

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Author Biographies

Paulo Sérgio Flores Campos, Federal University of Bahia

master's at Odontology from Universidade Federal da Bahia (1996) and ph.d. at Odontology from Universidade de São Paulo (2001). Has experience in Odontology, focusing on Odontology, acting on the following subjects: tomografia computadorizada por raios x, radiografia, radiografia dentária, articulação temporomandibular and ressonância magnética.

Sergio Roberto Peres Line, State University of Campinas

has graduation at Odontologia by Universidade Estadual de Campinas (1985) , Ph.D. at Patologia Experimental e Comparada by Universidade de São Paulo (1989) and Postdoctorate by National Institute Of Health (1991) . Currently is Servidor público ou celetista of Universidade Estadual de Campinas, Membro de corpo editorial of Journal of Applied Oral Science (Impresso), Membro de corpo editorial of Brazilian Journal of Oral Sciences (Impresso) e of Faculdade de Odontologia de Piracicaba-UNICAMP. Has experience in the area of Odontology. Focused, mainly, in the subjects: Laminina, Matriz extracelular, Menbrana Basal, Metaloproteases. 

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Published

2015-11-26

How to Cite

1.
Campos MIG, Campos PSF, Line SRP. Inflammatory cytokines activity in temporomandibular joint disorders: a review of literature. Braz. J. Oral Sci. [Internet]. 2015 Nov. 26 [cited 2022 Dec. 3];5(18):1054-62. Available from: https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8641896

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