Antiinflammatory activity of ricinus communis derived polymer

Authors

  • Adriana Cristina Valderramas
  • Sérgio Henrique Pereira Moura
  • Maira Couto Sacred Heart University, Bauru, SP
  • Silvana Pasetto University of Sagrado Coração, Bauru, SP, Brazil.
  • Gilberto Orivaldo Chierice University of São Paulo, São Carlos, SP, Brazil
  • Sérgio Augusto Catanzaro Guimarães
  • Ana Claudia Bensuaski de Paula Zurron University of Sagrado Coração, Bauru, SP, Brazil

DOI:

https://doi.org/10.20396/bjos.v7i27.8642494

Keywords:

Polymer, Ricinus communis, Phospholipase A2, Antiinflammatory activity

Abstract

Aim: The present study aimed to evaluate the antiinflammatory activity of the polymer derived from Ricinus communis and its mechanism of action. Methods: The antiinflammatory activity was investigated in chronic and acute animal models and the mechanism of action involved in the antiinflammatory activity was determined by the in vitro phospholipase A2 (PLA2 ) enzyme assay. Results: In mouse ear edema (10.0 mg/ear) and granulomatous tissue formation (500 mg/kg) models, the polymer inhibited the inflammatory response in 75.08 ± 1.80% and 61.70 ± 1.80% of the cases, respectively (p<0.001). Oral administration of the Ricinus communis polymer (500 mg/kg) inhibited 72.00 ± 1.20% of formalin-induced inflammation. Topical administration of the polymer on oral lesions of mice showed that the oral mucosa was recovered in 60.00 ± 1.40% (p<0.05) of the cases. In in vitro assay, the phospholipase A2 enzyme was inhibited by the Ricinus communis polymer (5.0 mg/mL) in a dose-dependent manner (84.60 ± 1.41%). Conclusion: the polymer derived from Ricinus communis showed a significant antiinflammatory activity, confirming that the pharmacological mechanism involved in this antiinflammatory action was related to the inhibition of the PLA2 enzyme.

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Author Biographies

Adriana Cristina Valderramas

Master Degree in Oral Biology, Prorector for Research and Postgraduate Affairs

Sérgio Henrique Pereira Moura

Undergraduate Student, Department of Biological Sciences

Maira Couto, Sacred Heart University, Bauru, SP

Biologist, Department of Biological Sciences, Sacred Heart University, Bauru, SP

Silvana Pasetto, University of Sagrado Coração, Bauru, SP, Brazil.

Professor, Prorector for Research and Postgraduate Affairs, Sacred Heart *University of Sagrado Coração, Bauru, SP, Brazil.

Gilberto Orivaldo Chierice, University of São Paulo, São Carlos, SP, Brazil

Professor, Institute of Chemistry of São Carlos, School of Engineering of São Carlos, University of São Paulo, São Carlos, SP, Brazil

Ana Claudia Bensuaski de Paula Zurron, University of Sagrado Coração, Bauru, SP, Brazil

Professor, Prorector for Research and Postgraduate Affairs, Sacred Heart *University of Sagrado Coração, Bauru, SP, Brazil

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Published

2015-12-23

How to Cite

1.
Valderramas AC, Moura SHP, Couto M, Pasetto S, Chierice GO, Guimarães SAC, Zurron ACB de P. Antiinflammatory activity of ricinus communis derived polymer. Braz. J. Oral Sci. [Internet]. 2015 Dec. 23 [cited 2023 Feb. 6];7(27):1666-72. Available from: https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8642494

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