Susceptibility of Susceptibility of Susceptibility of Candida Candida spp. Oral isolates for azolic spp. Oral isolates for azolic antifungals and amphotericin B

Authors

  • Vivian Fernandes Furlletti University of Campinas – UNICAMP
  • Rita de Cássia Mardegan University of Campinas – UNICAMP
  • Gustavo Alberto Obando-Pereda University of Campinas - UNICAMP
  • Paula Cristina Aníbal University of Campinas – UNICAMP, Campinas, SP, Brazil
  • Marta Cristina Texeira Duarte University of Campinas – UNICAMP
  • Reginaldo Bruno Gonçalves University of Campinas
  • José Francisco Höfling University of Campinas - UNICAMP

DOI:

https://doi.org/10.20396/bjos.v7i25.8642889

Keywords:

Periodontal disease, Candida spp., Antifungical, Minimal inhibitory concentration

Abstract

Aims: Among the oral infections, candidosis may be considered the most frequent, and C. albicans the most prevalent species. Meanwhile, the non-albicans species may also be related to other infections processes and be able to affect the oral cavity, including periodontal disease. In this sense, understanding the relationship between Candida spp. and host, it is necessary and justified the search of mechanisms modulators of infections and treatments against diseases associated with these yeasts. Methods: Nineteen patients with periodontal disease were involved in this study. The aim was evaluate the susceptibility to azoles antifungals fluconozole, itraconazole, ketoconazole and the polienic anfotericin B against Candida spp isolated from three different sites of the oral cavity from these patients (periodontal disease, being periodontal pocket, oral mucosa and ridge gingival), by the minimum inhibitory concentration method – MIC. Results: Among the samples of C. albicans, 88% showed susceptibility depending on the concentration (SCD) and 3.6 % were resistant to at least one antifungal azole studied. Among the others species, 57% presented SDC and 42.8% showed resistance to at least one of the antifungal azole tested. Regarding to Anfotericin B, 90% of the C. albicans isolates and 3% of the nonalbicans showed resistance. There was no occurrence of resistance to the fluconazole and only 3.6% of C. albicans and 40% of the non-albicans were SDC to this antifungal. Conclusions: Patients with periondontal disease showed relevant levels of colonization by Candida spp, mainly at the oral mucosa and periodontal pocket showing important occurrence of SDC and resistance to the antifungals drugs tested.

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Author Biographies

Vivian Fernandes Furlletti, University of Campinas – UNICAMP

Department of Microbiology and Immunology, Dental School of Piracicaba, University of Campinas - UNICAMP, Research Center for Chemistry, Biology and Agriculture, University of Campinas – UNICAMP, Campinas, SP, Brazil

Rita de Cássia Mardegan, University of Campinas – UNICAMP

Department of Microbiology and Immunology, Dental School of Piracicaba, University of Campinas - UNICAMP, Research Center for Chemistry, Biology and Agriculture, University of Campinas – UNICAMP, Campinas, SP, Brazil

Gustavo Alberto Obando-Pereda, University of Campinas - UNICAMP

Department of Microbiology and Immunology, Dental School of Piracicaba, University of Campinas - UNICAMP. Campinas SP

Paula Cristina Aníbal, University of Campinas – UNICAMP, Campinas, SP, Brazil

Department of Microbiology and Immunology, Dental School of Piracicaba, University of Campinas - UNICAMP, Research Center for Chemistry, Biology and Agriculture, University of Campinas – UNICAMP, Campinas, SP, Brazil

Marta Cristina Texeira Duarte, University of Campinas – UNICAMP

Research Center for Chemistry, Biology and Agriculture, University of Campinas – UNICAMP, Campinas, SP

Reginaldo Bruno Gonçalves, University of Campinas

Department of Microbiology and Immunology, Dental School of Piracicaba, University of Campinas - UNICAMP, Piracicaba, SP

José Francisco Höfling, University of Campinas - UNICAMP

Department of Microbiology and Immunology, Dental School of Piracicaba, University of Campinas - UNICAMP, 13414-903 Piracicaba, SP, Brazil

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Published

2016-01-15

How to Cite

1.
Furlletti VF, Mardegan R de C, Obando-Pereda GA, Aníbal PC, Duarte MCT, Gonçalves RB, Höfling JF. Susceptibility of Susceptibility of Susceptibility of Candida Candida spp. Oral isolates for azolic spp. Oral isolates for azolic antifungals and amphotericin B. Braz. J. Oral Sci. [Internet]. 2016 Jan. 15 [cited 2022 Aug. 18];7(25):1543-9. Available from: https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8642889

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