Antimicrobial activity of a propolis adhesive formulation on different oral pathogens


  • Rafael Tomaz Gomes Federal University of Minas Gerais
  • Karina Imaculada Rosa Teixeira Federal University of Minas Gerais
  • Maria Esperanza Cortés Federal University of Minas Gerais
  • Vagner Rodrigues Santos Federal University of Minas Gerais



Propolis, ointment. Oral bacteria. Oral fungi. Susceptibility, . MIC


Recent studies have shown that propolis has appreciable antibacterial, antifungal and antiviral actions, as well as cytostatic and antitumoral activity. In light of these studies, the antimicrobial activity of a new adhesive formulation containing propolis was evaluated in this in vitro study. Susceptibility of the oral strains tested (Candida albicans, Candida tropicalis, Streptococcus mutans, Staphylococcus aureus, Enterococcus faecalis, Actinomyces israelli, Actinobacillus actinomycetemcomitans) was evaluated using the agar diffusion method with different concentrations of propolis (5, 10, 15 and 20%). All of the assayed bacteria and fungi species were susceptible to propolis, with minimum inhibitory concentrations (MIC) ranging from 1.75 to 14.0 µg/ml. The positive results suggest that propolis in this sustained release formulation should be further tested as an alternative therapy of infectious conditions of the oral cavity, such as denture stomatitis and periodontitis. However, in vivo studies of the effect of this new adhesive formulation of propolis are needed to determine its possible effects on the oral mucosa.


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Author Biographies

Rafael Tomaz Gomes, Federal University of Minas Gerais

Graduado em Medicina pela Faculdade de Medicina da UFMG (FM-UFMG) e em Odontologia pela Faculdade de Odontologia da UFMG (FO-UFMG). Possui experiência de pesquisa na área de Estomatologia, com 15 artigos completos publicados, dos quais 5 se encontram indexados no PUBMED, e 23 resumos publicados em anais de congressos. 

Karina Imaculada Rosa Teixeira, Federal University of Minas Gerais

Possui mestrado e doutorado em Clínica Odontológica pela Universidade Federal de Minas Gerais . Tem experiência na área de Odontologia, atuando principalmente nos seguintes temas: biomateriais, microbiologia, cultura celular e liberação controlada de fármacos.

Maria Esperanza Cortés, Federal University of Minas Gerais

Atualmente é Professora Titular do Departamento de Odontologia Restauradora da Faculdade de Odontologia da Universidade Federal de Minas Gerais e Bolsista CNPq. Possui graduação em Odontologia - Universidad Del Valle -Cali/Colombia (1984), mestrado (1993) e doutorado (1999) em Odontologia (Clínica Integrada) pela Universidade de São Paulo. Estagio no Massachusetts Institute of Technology (1997-1999) na área de Biomateriais realizado no Biomedical Engineering Department. Professora orientadora do Curso de Pós-graduação em Odontologia na área de Clínica Odontológica e Periodontia, nível de Mestrado e Doutorado e do Curso de Mestrado Profissional Inovação biofarmacêutica do Departamento de Fisiologia do Instituto de Ciências Biológicas da UFMG.

Vagner Rodrigues Santos, Federal University of Minas Gerais

Pós-doutor em Farmacologia Clínica (Universidade da Califórnia em Berkeley, CA, EUA, 2012), Doutor em Ciências com ênfase em Patologia Bucal pela UFMG (1996), Mestre em Microbiologia pela UFMG e Institut National de Recherche Agronomique (INRA), Jouy-en-Josas, França (1990/1992), Aperfeiçoamento em Cirurgia Bucomaxilofacial (UFMG), é graduado em Odontologia (1980) pela Universidade Federal de Minas Gerais (UFMG). Professor Associado IV de Patologia Oral e Estomatologia do Departamento de Patologia, Clínica e Cirurgia da Faculdade de Odontologia da UFMG desde 1992. 


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How to Cite

Gomes RT, Teixeira KIR, Esperanza Cortés M, Santos VR. Antimicrobial activity of a propolis adhesive formulation on different oral pathogens. Braz. J. Oral Sci. [Internet]. 2016 Jan. 21 [cited 2022 Dec. 5];6(22):1387-91. Available from: