Parental age is related to the occurrence of cleft lip and palate in Brazilian populations

Authors

  • Paulo Henrique Pimenta de Carvalho Universidade Estadual de Montes Claros
  • Renato Assis Machado Universidade Estadual de Campinas
  • Silvia Regina de Almeida Reis Escola Bahiana de Medicina e Saúde Pública
  • Daniella Reis Barbosa Martelli Universidade Estadual de Montes Claros
  • Verônica Oliveira Dias Universidade Estadual de Montes Claros
  • Hercílio Martelli Júnior Universidade Estadual de Montes Claros

DOI:

https://doi.org/10.20396/bjos.v15i2.8648758

Keywords:

Cleft palate. Cleft lip. Paternal age. Maternal age. Risk factors.

Abstract

Aim: To evaluate the association of environmental risk factors, particularly paternal and maternal age, with gender and type of oral cleft in newborn with nonsyndromic cleft lip with or without cleft palate (NSCL/P). Methods: This study included 1,346 children with NSCL/P of two Brazilian Services for treatment of craniofacial deformities. Parental ages were classified into the following groups: maternal age <35, 36-39, and ≥40 years; paternal age <39 and ≥40 years. The data was analyzed with chi-square test and multinomial logistic regression analysis. The odds ratios were estimated with a 95% confidence interval. Results: Of the 1,346 children included in this study, CLP was the type of NSCL/P with highest prevalence, followed by, respectively, CL and CP. There was a greater occurrence of NSCL/P in males compared to females (55.8% versus 44.2%). CLP was more common in men, while the CL and CP were more prevalent in women (p=0.000). No association between maternal age and clefts was observed (p=0.747). However, there was evidence of association between father’s aged ≥40 years old and NSCL/P (p=0.031). When patients with CP were analyzed separately, no association between the father’s age and the child’s gender (p=0.728) was observed, i.e. the female gender prevails among patients with CP, regardless of the father’s age. Conclusions: This study showed that there were differences in the distribution of the non-syndromic cleft lip and/or palate and the gender, and fathers aged ≥40 years old may have increased risk of oral cleft. Further studies involving different populations are needed for a better understanding of the effect of maternal and paternal ages as a risk factor for the occurrence of oral clefts.

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Author Biographies

Paulo Henrique Pimenta de Carvalho, Universidade Estadual de Montes Claros

Graduado em Medicina pela Unimontes-MG ,mestrado em Cuidados Primários em Saúde pela Unimontes-MG, especialista em Otorrinolaringologia e Ciências da Saúde. Atua como médico otorrinolaringologista na Santa Casa de Caridade de Montes Claros, Hospital Universitário Clemente de Farias e Prefeitura Municipal de Montes Claros.

Renato Assis Machado, Universidade Estadual de Campinas

Graduado em Odontologia pela Universidade José do Rosário Vellano - Unifenas (2012). Possui mestrado em Estomatopatologia pela Faculdade de Odontologia de Piracicaba, da Universidade Estadual de Campinas - FOP/Unicamp. Atualmente, é aluno de doutorado em Estomatopatologia pela FOP-Unicamp.

Silvia Regina de Almeida Reis, Escola Bahiana de Medicina e Saúde Pública

Possui graduação em Odontologia pela Universidade Federal da Bahia , mestrado em Odontologia (Cirurgia e Traum. Buco-Maxilo Facial) pela Pontifícia Universidade Católica do Rio Grande do Sul e doutorado em Odontologia(Patologia) pela Universidade Livre de Berlim. 

Daniella Reis Barbosa Martelli, Universidade Estadual de Montes Claros

Possui graduação em Odontologia pela Universidade de Alfenas, especialização em Endodontia pela Universidade de Alfenas, especialização em Saúde Coletiva pela Associação Brasileira de Odontologia (ABO-Belo Horizonte-Minas Gerais), Mestrado em Ciências da Saúde pela Universidade Estadual de Montes Claros e Doutorado em Ciências da Saúde pela Universidade Estadual de Montes Claros.

Verônica Oliveira Dias, Universidade Estadual de Montes Claros

Possui graduação em Odontologia pela Pontifícia Universidade Católica de Minas Gerais, especialização em Odontopediatria pela APCD-Araraquara,especialização em Bioética pela Universidade Estadual de Montes Claros e mestrado interdisciplinar em Ciências da Saúde pelo Programa de Pós graduação em Ciências da Saúde da Universidade Estadual de Montes Claros.

Hercílio Martelli Júnior, Universidade Estadual de Montes Claros

É Professor Titular de Diagnóstico Bucal do Centro de Ciências Biológicas e da Saúde da Universidade Estadual de Montes Claros, Unimontes e Professor Permanente (Orientador de Mestrado e Doutorado) do Programa de Pós-Graduação em Ciências da Saúde e Cuidado Primário em Saúde da Universidade Estadual de Montes Claros. É Pró-Reitor de Pós-Graduação da Universidade Estadual de Montes Claros.

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Published

2017-04-20

How to Cite

1.
Carvalho PHP de, Machado RA, Reis SR de A, Martelli DRB, Dias VO, Martelli Júnior H. Parental age is related to the occurrence of cleft lip and palate in Brazilian populations. Braz. J. Oral Sci. [Internet]. 2017 Apr. 20 [cited 2022 Dec. 2];15(2):167-70. Available from: https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8648758

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