Banner Portal
Evaluation of antioxidant efficacy of Purslane extract in Patients with Recurrent Aphthous Stomatitis: a randomized, placebo-controlled, triple-blinded, clinical
PDF (Português (Brasil))


Recurrent aphthous stomatitis. Antioxidants. Purslane. Treatment.

How to Cite

Mohammadzadeh M, Rezaei N, Kamran E, Abdolhoseinpour F, Moqadam IF, Najafi S. Evaluation of antioxidant efficacy of Purslane extract in Patients with Recurrent Aphthous Stomatitis: a randomized, placebo-controlled, triple-blinded, clinical. Braz. J. Oral Sci. [Internet]. 2017 Aug. 11 [cited 2024 May 21];15(3):234-7. Available from:


Background: This herbal medicine is considered a rich source of antioxidants with anti-inflammatory effects. The purpose of this study was to evaluate the effectiveness of purslane in treatment of recurrent aphthous stomatitis (RAS) and also it ̓s effect on antioxidant level. Materials and methods: 50 patients were selected for this randomized triple-blind placebo-controlled trial. All subjects were randomly divided in to two groups, one group received purslane (n=25) and another group, placebo (n=25) for 3 month. Superoxide dismutase (SOD), glutathione peroxidase (GSHPx) and total antioxidant status (TAS) was measured in plasma at baseline and after 3 month of treatment. Also pain intensity based on the visual analogue scale (VAS), the mean interval between lesion, number of lesions and the mean duration of complete healing at baseline and in month 1, 2 and 3 were recorded. Statistical analysis was performed by using Mann-Whitney and T-test. Results: A significant decrease in pain intensity in VAS scores was seen after treatment in intervention group (p<0.001). The mean duration of complete healing showed significant differences (P<0.001) between the two groups. The mean interval between lesions also showed significant differences (P<0.001) among the intervention group (33.12 days) compared with the placebo group (17.88 days). No significant differences were found regarding the number of lesions, level of erythrocyte GSHPx, TAS and SOD. No serious side-effects occurred in either of groups. Conclusions: According to this study, purslane is clinically effective in treatment of RAS (number of lesions, pain intensity and duration of healing) although it is unable to change the level of antioxidants.
PDF (Português (Brasil))


Momen-Beitollahi J, Mansourian A, Momen-Heravi F, Amanlou M, Obradov S, Sahebjamee M. Assessment of salivary and serum antioxidant status in patients with recurrent aphthous stomatitis. Med Oral patol Oral cir bucal. 2010 Jul 1;15(4):e557-61.

Koybasi S, Parlak AH, Serin E, Yilmaz F, Serin D. Recurrent aphthous stomatitis: investigation of possible etiologic factors. Am J Otolaryngol. 2006 Jul-Aug;27(4):229-32.

Altenburg A, Zouboulis CC. Current concepts in the treatment of recurrent aphthous stomatitis. Skin therapy lett. 2008 Sep;13(7):1-4.

Jurge S, Kuffer R, Scully C, Porter SR. Number VI Recurrent aphthous stomatitis. Oral Dis. 2006 Jan 1;12(1):1-21.

Gurel A, Altinyazar HC, Unalacak M, Armutcu F, Koca R. Purine catabolic enzymes and nitric oxide in patients with recurrent aphthous ulceration. Oral Dis. 2007 Nov 1;13(6):570-4.

Movahedian A, Ghannadi A, Vashirnia M. Hypocholesterolemic effects of purslane extract on serum lipids in rabbits fed with high cholesterol levels. Int J Pharmacol. 2007;3(3):285-9.

Agha Hosseini F, Borhan Mojabi K, Monsef Esfahani HR, Mirzaii Dizgah I, Etemad Moghadam S, Karagah A. Efficacy of purslane in the treatment of oral lichen planus. Phytotherapy research. 2010 Feb 1;24(2):240-4.

Scott J, Huskisson EC. Graphic representation of pain. Pain. 1976 Jun 1;2(2):175-84.

Mimura MA, Hirota SK, Sugaya NN, Sanches Jr JA, Migliari DA. Systemic treatment in severe cases of recurrent aphthous stomatitis: an open trial. Clinics. 2009 Mar;64(3):193-8.

Azizi A, Shah Siah S, Madhani A. Comparison of amount of salivary total antioxidant in patients with recurrent aphtous stomatitis. J Dent Med. 2012 Apr 15;25(1):14-8.

Gunduz K, Ozturk G, Sozmen EY. Erythrocyte superoxide dismutase, catalase activities and plasma nitrite and nitrate levels in patients with Behcet disease and recurrent aphthous stomatitis. Clinical and experimental dermatology. 2004 Mar 1;29(2):176-9.

Saral Y, Coskun BK, Ozturk P, Karatas F, Ayar A. Assessment of salivary and serum antioxidant vitamins and lipid peroxidation in patients with recurrent aphthous ulceration. The Tohoku journal of experimental medicine. 2005;206(4):305-12.

Karincaoglu Y, Batcioglu K, Erdem T, Esrefoglu M, Genc M. The levels of plasma and salivary antioxidants in the patient with recurrent aphthous stomatitis. J Oral Pathol Med. 2005 Jan 1;34(1):7-12. 14. Arikan S, Durusoy C, Akalin N, Haberal A, Seckin D. Oxidant/antioxidant status in recurrent aphthous stomatitis. Oral Dis. 2009 Oct 1;15(7):512-5.

Ezekwe MO, Omara-Alwala TR, Membrahtu T. Nutritive characterization of purslane accessions as influenced by planting date. Plant Foods Hum Nutr. 1999;54(3):183-91.

Simopoulos AP, Norman HA, Gillaspy JE, Duke JA. Common purslane: a source of omega-3 fatty acids and antioxidants. J Am Coll Nutr. 1992 Aug;11(4):374-82.

Liu C, Zhou Z, Liu G, Wang Q, Chen J, Wang L, et al. Efficacy and safety of dexamethasone ointment on recurrent aphthous ulceration. Am J Med. 2012 Mar 31;125(3):292-301.

Stephen J. Challacombe, Surab Alsahaf, Anwar Tappuni. Recurrent Aphthous Stomatitis: Towards Evidence-Based Treatment?. Curr Oral Health Rep. 2015. 2: 158.

Leung YY, Hui LL, Kraus VB. Colchicine—Update on mechanisms of action and therapeutic uses. InSeminars in arthritis and rheumatism 2015 Dec 31: 45(3): 341-350.

The Brazilian Journal of Oral Sciences uses the Creative Commons license (CC), thus preserving the integrity of the articles in an open access environment.


Download data is not yet available.