Profiling of pro-inflammatory cytokines in radiation induced oral mucositis (riom) among indian patients

  • Akanksha Marwah Jamia Millia Islamia
  • Zaffar Iqbal Jamia Millia Islamia
  • Md. Zafaryab Jamia Millia Islamia
  • Mahesh Verma Jamia Millia Islamia
  • Moshahid MA Rizvi Jamia Millia Islamia
  • Sunita Gupta Jamia Millia Islamia
Keywords: Mucositis. NF-κβ. Proinflammatory cytokines. Radiation therapy.

Abstract

Radiation-induced oral mucositis (RIOM) is aimed at evaluating the expression of NF-κβ, IL-1α, IL-6, IL-8 and TNF-α in patients with RIOM so as to validate their role in the pathobiology of the disease. Blood samples were collected and serum of 45 patients isolated with clinical signs and symptoms of mucositis and 10 healthy controls were also included in the study. The expression level of NF-κβ, IL-1α, IL-6, IL-8, TNF-α was investigated using ELISA. Mann Whitney U test was applied to find the significance of the expression of these markers in RIOM patients as compared to normal healthy controls and significant  expression (P< 0.05) for NF-κβ, IL-6, TNF-α and non-significant  expression (P > 0.05) IL-1α and IL-8 was found. No significant change in the expression level of the cytokines was observed for patients undergoing chemotherapy and radiation therapy as well as those receiving only the radiation therapy as a part of their treatment. We have also found less expression in grade 1 of mucositis as compared to grade 4. Pro- inflammatory cytokines indeed play a vital role in the pathogenesis as well as progression of RIOM.

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Author Biographies

Akanksha Marwah, Jamia Millia Islamia
Pharmacovigilance associate na APCER Life Sciences
Zaffar Iqbal, Jamia Millia Islamia
Otolaryngology. Self-Designated Expertise.
Md. Zafaryab, Jamia Millia Islamia
Department of Biosciences at Jamia Millia Islamia, New Delhi.
Mahesh Verma, Jamia Millia Islamia
Director and Principal of Maulana Azad Institute of Dental Sciences.
Moshahid MA Rizvi, Jamia Millia Islamia

Genome Biology Lab, Department of Biosciences.

Sunita Gupta, Jamia Millia Islamia
Doctor at Max Healthcare, specialized in Obstetrics And Gynaecology.

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Published
2017-09-20
How to Cite
Marwah, A., Iqbal, Z., Zafaryab, M., Verma, M., Rizvi, M. M., & Gupta, S. (2017). Profiling of pro-inflammatory cytokines in radiation induced oral mucositis (riom) among indian patients. Brazilian Journal of Oral Sciences, 15(4), 280-285. https://doi.org/10.20396/bjos.v15i4.8650040
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