Analysis of MMP-3 polymorphism in osseointegrated implant failure

  • Francielle Boçon de Araujo Munhoz Universidade Federal do Paraná
  • Paula Regina Bach Nogara Universidade Federal do Paraná
  • Francisco Rafael da Costa Junior ESIC Business & Marketing School
  • Filipe Polese Branco Faculdade Avantis
  • Maria Cristina Leme Godoy dos Santos Universidade Federal do Paraná
Keywords: Polymorphism. Metalloproteinase. Implant loss. Risk factor.

Abstract

Polymorphisms in matrix metalloproteinases (MMPs) genes have been associated with several pathologies, including dental implant loss. MMP-3 is crucial to the connective tissue remodeling process. The objective of this study was to investigate the possible relationship between -1612 MMP-3 polymorphism and the early implant failure. A sample of 240 non-smokers was divided: test group 120 patients with one or more early failed implants and control group 120 patients with one or more healthy implants. Genomic DNA from oral mucosa was analyzed by PCR-RFLP. No association of early implant loss with genotypes and alleles of the -1612 polymorphism in MMP-3 were found by the Chi-squared test. Only the presence of the -1612 polymorphism of MMP-3 is not a genetic risk factor for early loss of implants.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Author Biographies

Francielle Boçon de Araujo Munhoz, Universidade Federal do Paraná
Doutoranda em Biologia Celular e Molecular pela Universidade Federal do Paraná. Possui Mestrado em Biologia Celular e Molecular (2014) e Especialização em Biologia Celular e Tecidual pela Universidade Federal do Paraná (2010), Graduação em Ciências Biológicas pelo Centro Universitário Campos de Andrade (2007). Atualmente dedica-se a pesquisa na área Biológica. Possui experiência consolidada em biologia molecular, análises laboratoriais de sorologia e tipagem sanguínea, análises microbiológicas, qualidade, assessoria científica de materiais e equipamentos de laboratório e apoio técnico-científico à clientes.
Paula Regina Bach Nogara, Universidade Federal do Paraná
Possui graduação em Farmácia Generalista pela UNIDADE DE ENSINO SUPERIOR VALE DO IGUAÇU - UNIGUAÇU (2007). Especialista em Citologia Clínica pelo Conselho Regional de Farmácia do Paraná - CRF/PR (2008).Mestre em biociências aplicadas à Farmácia na Universidade Estadual de Maringá - UEM, com ênfase em diagnóstico citológico e molecular do HPV. Doutoranda em Biologia Celular e Molecular pela Universidade Federal do Paraná - UFPR.
Francisco Rafael da Costa Junior, ESIC Business & Marketing School
Farmacêutico Graduado pela Universidade Federal do Paraná - UFPR, pós graduado em Farmacologia Aplicada pela CBES e Mestre em Biologia Celular e Molecular pelo departamento da BIOMOL da UFPR. Atualmente, cursando MBA em Marketing e Gestão de Negócios na ESIC Business & Marketing School. Experiência em Farmacologia com ênfase em sistema nervoso central, Biologia Celular e Molecular com ênfase em polimorfismos genéticos de MMP´s, Marketing com ênfase em marketing farmacêutico e gestão de propaganda médica.
Filipe Polese Branco, Faculdade Avantis
Doutor em Odontologia pela UNICAMP (2008) Mestre em Farmacologia, Anestesiologia e Terapêutica pela UNICAMP (2003) Especialista em Implantodontia (2014) Habilitação Sedação Consciente com Óxido Nitroso (2005) Graduado em Odontologia pela Universidade do Vale do Itajaí (2001) Professor de Farmacologia, Anestesiologia e Cirurgia na Faculdade Avantis - Balneário Camboriú Diretor do Instituto de Pós graduação e Pesquise em Odontologia - Instituto IPPO - Balneário Camboriú
Maria Cristina Leme Godoy dos Santos, Universidade Federal do Paraná
Possui graduação em Odontologia pela Universidade Estadual de Campinas (2001), mestrado, doutorado e pós-doutorado em Biologia Buco-Dental pela Universidade Estadual de Campinas (2004 - 2006 - 2007). Parte do doutorado realizou no National Institutes of Health, em Bethesda, Estados Unidos. Atualmente é professora efetiva da Universidade Federal do Paraná - Departamento de Biologia Celular. Tem experiência na área de Histologia e Biologia Celular, atuando principalmente nos seguintes temas: polimorfismo genético, metaloproteases e citocinas.

References

Holm-Pedersen P, Lang NP, Muller F. What are the longevities of teeth and oral implants? Clin Oral Implants Res. 2007 Jun;18 Suppl 3:15-9.

Chrcanovic BR, Albrektsson T, Wennerberg A. Reasons for failures of oral implants. J Oral Rehabil. 2014 Jun;41(6):443-76. doi: 10.1111/joor.12157.

Porter JA, Von Fraunhofer JÁ. Success or failure of dental implants? A literature review with treatment considerations. Gen Dent. 2005 Nov-Dec;53(6):423-32; quiz 433, 446. 4. Weyant RJ, Burt BA. An assessment of survival rates and within-patient clustering of failures for endosseous oral implants. J Dental Res. 1993 Jan;72(1):2-8.

Santos MC, Campos M, Souza AP, Trevilatto PC, Line SR. Analysis of MMP-1 and MMP-9 promoter polymorphisms in early osseointegrated implant failure. Int J Oral Maxillofac Implants. 2004 Jan-Feb;19(1):38-43.

Leite MFF, Santos MCLG, Souza AP, Line SRP. Osseintegrated implant failure associeted with MMP-1 promoter polymorphisms (-1607 and -519). Int J Oral Maxillofac Implants. 2008 Jul-Aug;23(4):653-8.

Costa-Junior FR, Alvim-Pereira CC, Alvim-Pereira F, Trevilatto PC, de Souza AP, Santos MC. Influence of MMP-8 promoter polymorphism in early osseointegrated implant failure. Clin Oral Investig. 2013 Jan;17(1):311-6. doi: 10.1007/s00784-012-0699-z.

Cauwe B, Van den Steen PE, Opdenakker G. The biochemical, biological, and pathological kaleidoscope of cell surface substrates processed by matrix metalloproteinases. Crit Rev Biochem Mol Biol. 2007 May-Jun;42(3):113-85.

Ramseier CA, Eick S, Brönnimann C, Buser D, Brägger U, Salvi GE. Host-derived biomarkers at teeth and implants in partially edentulous patients. A 10-year retrospective study. Clin Oral Implants Res. 2016 Feb;27(2):211-7. doi: 10.1111/clr.12566.

Johnson JL, Dwivedi A, Somerville M, George SJ, Newby AC. Matrix metalloproteinase (MMP)-3 activates MMP-9 mediated vascular smooth muscle cell migration and neointima formation in mice. Arterioscler Thromb Vasc Biol. 2011 Sep;31(9):e35-44. doi: 10.1161/ ATVBAHA.111.225623.

Woessner J. Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J. 1991 May;5(8):2145-54.

Leong DJ, Gu XI, Li Y, Lee JY, Laudier DM, Majeska RJ, et al. Matrix metalloproteinase-3 in articular cartilage is up-regulated by joint immobilization and suppressed by passive joint motion. Matrix Biol. 2010 Jun;29(5):420-6. doi: 10.1016/j.matbio.2010.02.004

Ito A, Mukaiyama A, Itoh Y, Nagase H, Thogersen IB, Enghild JJ, et al. Degradation of interleukin 1beta by matrix metalloproteinases. J Biol Chem. 1996 Jun 21;271(25):14657-60.

Astolfi CM, Shinohara AL, Da Silva RA, Santos MC, Line SR, De Souza AP. Genetic polymorphisms in the MMP-1 and MMP-3 gene may contribute to chronic periodontitis in a Brazilian population. J Clin Periodontol. 2006 Oct;33(10):699-703.

Aidar M, Line SR. A simple and cost-effective protocol for DNA isolation from buccal epithelial cells. Braz Dent J. 2007;18(2):148-52.

Schneider S, D Roessli, L Excoffier. Arlequin v.2.000: software for population genetics data analysis. User manual: ver. 2.000. Geneva, Switzerland: Genetics and Biometry Laboratory, University of Geneva; 2000.

Seymour GJ, Gemmell E, Lenz LJ, Henry P, Bower R, Yamazaki K. Immunohistologic analysis of the inflammatory infiltrates associated with osseointegrated implants. Int J Oral Maxillofac Implants. 1989 Fall;4(3):191-8.

Greenstein G, Hart TC. Clinical utility of a genetic susceptibility test for severe chronic periodontitis: a critical evaluation. J Am Dent Assoc. 2002 Apr;133(4):452-9; quiz 492-3.

Cosyn J, Christiaens V, Koningsveld V, Coucke PJ, De Coster P, De Paepe A, et al. An Exploratory Case-Control Study on the Impact of IL-1 Gene Polymorphisms on Early Implant Failure. Clin Implant Dent Relat Res. 2016 Apr;18(2):234-40. doi: 10.1111/cid.12237.

Montes CC, Alvim-Pereira F, De Castilhos BB, Sakurai ML, Olandoski M, Trevilatto PC. Analysis of the association of IL1B (C+3954T) and IL1RN (intron 2) polymorphisms with dental implant loss in a Brazilian population. Clin Oral Implants Res. 2009 Feb;20(2):208-17. doi: 10.1111/j.1600-0501.2008.01629.x.

Pigossi SC, Alvim-Pereira F, Alvim-Pereira CC, Trevilatto PC, ScarelCaminaga RM. Association of interleukin 4 gene polymorphisms with dental implant loss. Implant Dent. 2014 Dec;23(6):723-31. doi: 10.1097/ ID.0000000000000157.

Campos MI, Godoy dos Santos MC, Trevilatto PC, Scarel-Caminaga RM, Bezerra FJ, Line SR. Interleukin-2 and interleukin-6 gene promoter polymorphisms, and early failure of dental implants. Implant Dent. 2005 Dec;14(4):391-6.

Gurol C, Kazazoglu E, Dabakoglu B, Korachi M. A comparative study of the role of cytokine polymorphisms interleukin-10 and tumor necrosis factor alpha in susceptibility to implant failure and chronic periodontitis. Int J Oral Maxillofac Implants. 2011Sep-Oct;26(5):955-60.

Liao J, Li C, Wang Y, Ten M, Sun X, Tian A, et al. Meta-analysis of the association between common interleukin-1 polymorphisms and dental implant failure. Mol Biol Rep. 2014 May;41(5):2789-98. doi: 10.1007/ s11033-014-3133-6.

Dereka X, Mardas N, Chin S, Petrie A, Donos N. A systematic review on the association between genetic predisposition and dental implant biological complications. Clin Oral Implants Res. 2012 Jul;23(7):775-88. doi: 10.1111/j.1600-0501.2011.02329.x.

Esposito M, Hirsch JM, Lekholm U, Thomsen P. Biological factors contributing to failures of osseointegrated oral implants. (I). Success criteria and epidemiology. Eur J Oral Sci. 1998 Feb;106(1):527-51.

Published
2017-09-20
How to Cite
Munhoz, F. B. de A., Nogara, P. R. B., Junior, F. R. da C., Branco, F. P., & Santos, M. C. L. G. dos. (2017). Analysis of MMP-3 polymorphism in osseointegrated implant failure. Brazilian Journal of Oral Sciences, 15(4), 304-307. https://doi.org/10.20396/bjos.v15i4.8650045
Section
Article