Fungal and viral oral infections in individuals with onco-hematologic neoplasms in a University Hospital
AbstractIntroduction: Individuals undergoing onco-hematologic treatment present higher risk for developing oral and/or systemic infections, due to the intense immunosuppression and compromise of the mucosal barriers during treatment. The aim of this study was to identify the fungal and viral oral infections that most frequently affected patients undergoing onco-hematologic treatment in a University Hospital, and relate them to the biopsychosocial data, underlying disease and treatment. Methods: This was a crosssectional study in which descriptive analysis of the data was performed, and the Exact Fisher test was applied to verify the association between the infections and the variables: sex, age group, educational level, underlying disease and treatment, considering a 5% probability of error. Results and Discussion: The clinical exam revealed that oral candidiasis was present in 8.92% of the individuals, and herpes simplex, in 4.5%. No significant associations were found between the variables and infections. The fungal and viral oral infections were little prevalente in individuals with hematologic neoplasms in the present study, suggesting that the action of dental surgeons in caring for the onco-hematologic patients at the Institution evaluated and the protocols use were efficient.
Rizzo JD, Wingard JR, Tichelli A, Lee SJ, Van Lint MT, Burns LJ, et al. Recommended screening and preventive practices for long-term survivors after hematopoietic cell transplantation: joint recommendations of the European Group for Blood and Marrow Transplantation, the Center for International Blood and Marrow Transplant Research, and the American Society of Blood and Marrow Transplantation. Biol Blood Marrow Transplant. 2006 Feb;12(2):138-51.
McGuire DB, Correa MEP, Johnson J, Wienandts P. The role of basic oral care and good clinical practice principles in the management of oral mucositis. Support Care Cancer. 2006 Jun;14(6):541-7.
Brennan MT, Elting LS, Spijkervet FKL. Systematic reviews of oral complications from cancer therapies, Oral Care Study Group, MASCC/ ISOO: methodology and quality of the literature. Support Care Cancer. 2010 Aug;18(8):979-84. doi: 10.1007/s00520-010-0856-3.
Majorana A, Schubert MM, Porta F, Ugazio AG, Sapelli PL. Oral complications of pediatric hematopoietic cell transplantation: diagnosis and management. Support Care Cancer. 2000 Sep;8(5):353-65.
Da Silva Santos PS, Guaré RO, Fachin LV, Correa MSNP. [Bone marrow transplant: general considerations and oral manifestations in pediatric patients]. Rev Assoc Paul Cir Dent. 2008;62(6):450-4. Portuguese.
Lalla RV, Latortue MC, Hong CH, Ariyawardana A, D'Amato-Palumbo S, Fischer DJ, et al. A systematic review of oral fungal infections in patients receiving cancer therapy. Support Care Cancer. 2010 Aug;18(8):985-92. doi: 10.1007/s00520-010-0892-z.
Gligorov J, Bastit L, Gervais H, Henni M, Kahila W, Lepille D, et al. Prevalence and treatment management of oropharyngeal candidiasis in cancer patients: results of the French CANDIDOSCOPE study. Int J Radiat Oncol Biol Phys. 2011 Jun 1;80(2):532-9. doi: 10.1016/j. ijrobp.2010.02.006.
Reboli AC, Shorr AF, Rotstein C, Pappas PG, Kett DH, Schlamm HT, et al. Anidulafungin compared with fluconazole for treatment of candidemia and other forms of invasive candidiasis caused by Candida albicans: a multivariate analysis of factors associated with improved outcome. BMC Infect Dis. 2011 Sep 30;11:261. doi: 10.1186/1471-2334-11-261.
Gürgan CA, Özcan M, Karaku ş Ö, Zincircio ğlu G, Arat M, Soydan E, et al. Periodontal status and post ‐transplantation complications following intensive periodontal treatment in patients underwent allogenic hematopoietic stem cell transplantation conditioned with myeloablative regimen. Int J Dent Hyg. 2013 May;11(2):84-90. doi: 10.1111/j.16015037.2012.00550.x.
Palmason S, Marty FM, Treister NS. How do we manage oral infections in allogeneic stem cell transplantation and other severely immunocompromised patients? Oral Maxillofac Surg Clin North Am. 2011 Nov;23(4):579-99, vii. doi: 10.1016/j.coms.2011.07.012.
Chen YK, Hou HA, Chow JM, Chen YC, Hsueh PR, Tien HF. The impact of oral herpes simplex virus infection and candidiasis on chemotherapyinduced oral mucositis among patients with hematological malignancies. Eur J Clin Microbiol Infect Dis. 2011 Jun;30(6):753-9. doi: 10.1007/ s10096-010-1148-z.
Glenny AM, Fernandez Mauleffinch LM, Pavitt S, Walsh T. Interventions for the prevention and treatment of herpes simplex virus in patients being treated for cancer. Cochrane Database Syst Rev. 2009 Jan 21;(1):CD006706. doi: 10.1002/14651858.CD006706.pub2.
Bello-Silva MS, de Freitas PM, Aranha AC, Lage-Marques JL, Simões A, de Paula Eduardo C. Low-and high-intensity lasers in the treatment of herpes simplex virus 1 infection. Photomed Laser Surg. 2010 Feb;28(1):135-9. doi: 10.1089/pho.2008.2458.
Naylor GD, Marino GG, Shumway RC. Glossodynia after radiation therapy and chemotherapy. Ear Nose Throat J. 1989 Oct;68(10):751-7.
Teh BW, Slavin MA, Harrison SJ, Worth LJ. Prevention of viral infections in patients with multiple myeloma: the role of antiviral prophylaxis and immunization. Expert Rev Anti Infect Ther. 2015;13(11):1325-36. doi: 10.1586/14787210.2015.1083858.
Neville BW, Damm DD, Chi AC, Allen CM. Oral and maxillofacial pathology. Saint Louis: Elsevier Health Sciences; 2015.
Gomez RS, Carneiro MA, Souza LN, Victória JM, de Azevedo WM, De Marco L, et al. Oral recurrent human herpes virus infection and bone marrow transplantation survival. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001 May;91(5):552-6.
Yahav D, Gafter-Gvili A, Muchtar E, Skalsky K, Kariv G, Yeshurun M, et al. Antiviral prophylaxis in haematological patients: systematic review and meta-analysis. Eur J Cancer. 2009 Dec;45(18):3131-48. doi: 10.1016/j. ejca.2009.08.010.
Braunwald, E, Harrison TR. Harrison's principles of internal medicine. 2001. New York: McGraw-Hill Professional Publishing; 2001. v.1.
Soysa NS, Samaranayake LP, Ellepola ANB. Cytotoxic drugs, radiotherapy and oral candidiasis. Oral Oncology. 2004 Nov;40(10):9718.
Xu L, Zhang H, Liu J, Chen X. Investigation of the oral infections and manifestations seen in patients with advanced cancer. Pak J Med Sci. 2013 Sep;29(5):1112-5.
Tacke D, Buchheidt D, Karthaus M, Krause SW, Maschmeyer G, Neumann S, et al. Primary prophylaxis of invasive fungal infections in patients with haematologic malignancies. 2014 update of the recommendations of the Infectious Diseases Working Party of the German Society for Haematology and Oncology. Ann Hematol. 2014 Sep;93(9):1449-56. doi: 10.1007/s00277-014-2108-y.
The Brazilian Journal of Oral Sciences uses the Creative Commons license (CC), thus preserving the integrity of the articles in an open access environment.