Banner Portal
Association between hypertelorism and nonsyndromic oral clefts


Letter to the editor.

How to Cite

Nasser LS, Barros LM de, Martelli DRB, Tonelli JVQ, Swerts MSO, Martelli Júnior H. Association between hypertelorism and nonsyndromic oral clefts. Braz. J. Oral Sci. [Internet]. 2018 Nov. 26 [cited 2023 Dec. 9];17:e18287. Available from:


Hypertelorism is characterized by the increased distance between the orbits, measured from the most medial portion of its inner walls. It represents a signal found in sev eral craniofacial defects, and oral clefts. Nonsyndromic oral clefts (NOC) are the most common orofacial birth defect, occurring in 1 in 500-2,500 live births worldwide. NOC is caused by a complex interplay between environ mental exposures and genetic factors.



Costaras M, Pruzansky S, Broadbent BH Jr. Bony interorbital distance (BIOD), head size, and level of the cribriform plate relative to orbital height: I. Normal standards for age and sex. J Craniofac Genet Dev Biol. 1982;2(1):5-18.

Tan ST, Mulliken JB. Hypertelorism: nosologic analysis of 90 patients. Plast Reconstr Surg. 1997 Feb;99(2):317-27.

Dixon MJ, Marazita ML, Beaty TH, Murray JC. Cleft lip and palate: understanding genetic and environmental influences. Nat Rev Genet. 2011 Mar;12(3):167-78. doi: 10.1038/nrg2933.

Cohen MM, Richieri-Costa A, Guion-Almeida ML, Saavedra D. Hypertelorism: interorbital growth, measurements and pathogenetic considerations. J. Oral Maxillofac Surg. 1995 Dec;24(6):387-95.

Weinberg SM, Leslie EJ, Hecht JT, Wehby GL, Deleyiannis FWB, Moreno LM, et al. Hypertelorism and Orofacial Clefting Revisited: An Anthropometric Investigation. Cleft Palate Craniofac J. 2017 Nov;54(6):631-8. doi: 10.1597/15-256.

The Brazilian Journal of Oral Sciences uses the Creative Commons license (CC), thus preserving the integrity of the articles in an open access environment.


Download data is not yet available.


Metrics Loading ...