Fluoride concentration and stability in commonly used dentifrices in Sri Lanka
Keywords:Fluorides. Dental caries. Dentifrices.
AbstractAccording to the best scientific evidence, a dentifrice should contain 1000 ppm F or above but to guarantee the anti-caries efficacy this concentration should be chemically soluble and remain stable until the dentifrice expiration date. This stability depends on the type of abrasive and fluoride salt used in the formulation. Nine brands of dentifrices purchased in the Sri Lankan market were evaluated. The total fluoride (TF = soluble + insoluble) and total soluble fluoride (TSF = ion MFP + ion F-) concentrations were determined in fresh samples and after storage at room temperature and after accelerated aging. The analyses were made with an ion specific electrode using a validated analytical method. Three dentifrices were formulated with MFP/CaCO3, two with MFP/Silica, two with NaF/Silica and two were not fluoridated. The TF concentration found was very close to the concentration declared by the manufacturer. However, even in the fresh sample of one dentifrice formulated with MFP/CaCO3, there was insoluble fluoride (22%). The TSF concentration in all MFP/CaCO3-based dentifrices decreased with storage while insoluble fluoride had increased. The dentifrices formulated with MFP/Silica and NaF/Silica showed chemical stability. This is the first study done about the chemical quality of fluoride dentifrices marketed in Sri Lanka and the findings are an alert for a surveillance system in the country.
Cury JA, Tenuta LMA. How to maintain a cariostatic fluoride concentration in the oral environment. Adv Dent Res. 2008 Jul 1;20(1):13-6.
Shellis RP, Duckworth RM. Studies on the cariostatic mechanisms of fluoride. Int Dent J. 1994 Jun;44(3 Suppl 1):263-73.
Brattall D, Hansel-Peterson G, Sunberg H. Reason for the caries decline: What do the experts believe? Eur J Oral Sci. 1996 Aug;104(4 ( Pt 2)):416-22; discussion 423-5, 430-2.
Cury JA, Tenuta LM, Ribeiro CC, PaesLeme AF. The importance of fluoride dentifrices to the current dental caries prevalence in Brazil. Braz Dent J. 2004;15(3):167-74.
Birkeland JM, Haugejorden O, von der Fehr FR. Some factors associated with the caries decline among Norwegian children and adolescents: age-specific and cohort analyses. Caries Res. 2000;34(2):109-16. doi: 10.1159/000016577.
Tenuta LM, Cury JA. Laboratory and human studies to estimate anticaries efficacy of fluoride toothpastes. Monogr Oral Sci. 2013;23:108-24. doi: 10.1159/000350479.
Ricomini Filho AP, Tenuta LMA, Fernandes FS, Calvo AFB, Kusano SC, Cury JA. Fluoride concentration in the top-selling Brazilian toothpastes purchased at different regions. Braz Dent J 2012;23(1):45-8.
Walsh T, Worthington HV, Glenny AM, Appelbe P, Marinho VC, Shi X. Fluoride toothpastes of different concentrations for preventing dental caries in children and adolescents. Cochrane Database Syst Rev. 2010 Jan 20;(1):CD007868. doi: 10.1002/14651858.CD007868.pub2.
Freitas JF. Fluoride stability in toothpastes. Aust Dent J. 1984 Feb;29(1):30-5.
Hashizume LN, Lima YB, Kawaguchi Y, Cury JA. Fluoride availability and stability of Japanese dentifrices. J Oral Sci. 2003 Dec;45(4):193-9.
Matias JB, Azevedo CS, do Vale HF, Rebelo MA, Cohen-Carneiro F. Fluoride stability in dentifrices stored in schools in a town of northern Brazil. Braz Oral Res. 2015;29(1):S1806-83242015000100304. doi: 10.1590/1807-3107BOR-2015.vol29.0121.
Sri Lanka. Ministry of Health and Nutrition. National Oral Health Survey 1994-1995.
Sri Lanka. Ministry of Health and Nutrition. National Oral Health Survey 2002-2003.
Cury JA, Oliveira MJ, Martins CC, Tenuta LM, Paiva SM. Available fluoride in toothpastes used by Brazilian children. Braz Dent J. 2010;21(5):396-400.
Tabchoury CPM, Cury JA. [Study of toothpaste aging conditions to predict fluoride behavior in environment conditions]. Rev Bras Farm. 1994;75(3):67-71. Portuguese.
Martínez-Mier EA, Cury JA, Heilman JR, Katz BP, Levy SM, Li Y, et al. Development of gold standard ion-selective electrode-based methods for fluoride analysis. 2011;45(1):3-12. doi: 10.1159/000321657.
dos Santos AP, Nadanovsky P, de Oliveira BH. A systematic review and meta-analysis of the effects of fluoride toothpastes on the prevention of dental caries in the primary dentition of preschool children. Evid Based Dent. 2014; 1: 5. Evid Based Dent. 2014 Sep;15(3):67. doi: 10.1038/sj.ebd.6401035.
Abdul-Kadir R, Abdol-Latif L. Fluoride levels in dentifrices. Ann Dent Univ Malaya. 1998;5:2-5.
Sebastian ST and Siddanna S. Total and free fluoride concentration in various brands of toothpastes marketed in India. J Clin Diagn Res. 2015 Oct;9(10):ZC09-12. doi: 10.7860/JCDR/2015/13382.6578.
Conde NC, Rebelo MA, Cury JA. Evaluation of the fluoride stability of dentifrices sold in Manaus, AM, Brazil. Pesqui Odontol Bras. 2003 Jul-Sep;17(3):247-53.
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