Mast cell degranulation in periodontal disease from HIV-infected individuals

Keywords: Mast cells, Infection, Inflammation, Humans, Mouth mucosa.

Abstract

Aim: The objective was to compare the density and degranulation of mast cells on specimens obtained from individuals diagnosed with gingivitis or chronic periodontitis who were either non-HIV-infected or HIV-infected patients treated with highly active antiretroviral therapy (HAART). Methods: Gingival samples were taken from 16 non-HIV-infected individuals and 17 HIV-infected individuals diagnosed with gingivitis and chronic periodontitis. The samples were processed and stained with 0.3 percent o-toluidine blue. Densities (cells/mm²) and percentages of intact and degranulated mast cells were obtained. Results: No statistically significant differences were observed in the mast cell density and the percentage of degranulated mast cells between non-HIV-infected and HIV-infected individuals diagnosed with gingivitis and chronic periodontitis. Mononuclear inflammatory infiltrate was weakly correlated with the percentage of mast cells degranulated for both groups. Conclusions: There are no differences of the density and degranulation of mast cells in gingival tissue between non-HIV-infected and HIV-infected patients undergoing HAART, both groups with diagnosis of gingivitis or chronic periodontitis. This may be a result of the recovery of the immunologic system by HAART treatment.

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Author Biographies

Giovanna Ribeiro Souto, Pontifical Catholic University of Minas Gerais

PhD and postdoc in Dentistry, Federal University of Minas Gerais. Professor at the Department of Dentistry of the Pontifical Catholic University of Minas Gerais.

Alessandro Oliveira de Jesus, Federal University of Minas Gerais

Resident in Buccomaxillofacial Surgery and Traumatology, Minas Gerais State Hospital Foundation, João XXIII Hospital. Master in Stomatology, Federal University of Minas Gerais.

Takeshi Kato Segundo, Federal University of Minas Gerais

Masters and Doctorate in Periodontics, School of Dentistry, Federal University of Minas Gerais.

Paôlla Freitas Perdigão, D’OR Institute for Research and Education

PhD in Biochemical and Molecular Pharmacology, Federal University of Minas Gerais. D’OR Institute for Research and Education at Rio de Janeiro.

Fernando de Oliveira Costa, Federal University of Minas Gerais

Department of Oral Surgery and Pathology - School of Dentistry - Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Ricardo Alves de Mesquita, Federal University of Minas Gerais

Doctorate in Dentistry, University of São Paulo. Professor, School of Dentistry, Federal University of Minas Gerais.

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Published
2019-09-10
How to Cite
Souto, G. R., Jesus, A. O. de, Kato Segundo, T., Perdigão, P. F., Costa, F. de O., & Mesquita, R. A. de. (2019). Mast cell degranulation in periodontal disease from HIV-infected individuals. Brazilian Journal of Oral Sciences, 18, e191445. https://doi.org/10.20396/bjos.v18i0.8656600

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