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Factors associated with advanced-stage oral and oropharyngeal squamous cell carcinoma in a Brazilian population
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Keywords

Education status
Mouth neoplasms
Oropharyngeal neoplasms
Socioeconomic factors

How to Cite

1.
Pedra RC, Silva CL Álvares da, Bernardes IE, Verner FS, Andrade KM, de Sousa Santos R, et al. Factors associated with advanced-stage oral and oropharyngeal squamous cell carcinoma in a Brazilian population. Braz. J. Oral Sci. [Internet]. 2021 Jun. 17 [cited 2024 Apr. 16];20(00):e219638. Available from: https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8659638

Abstract

Diagnosis of oral and oropharyngeal cancer in advanced stages may be associated with social nature factors, access to health care, education, occupation, and behavioral/ cultural factors. Aim: To determine the factors related to high clinical-staging in patients diagnosed with squamous cell carcinoma in the oral and oropharyngeal region in a Cancer Center in Brazil between 2009 and 2015. Methods: It is an epidemiological, retrospective, and exploratory study. Patients diagnosed with squamous cell carcinoma had their medical records analyzed. The variables considered were sociodemographic, lifestyle, and disease characteristics. Descriptive and exploratory tests (Pearson’s, chi-square test and, Student’s t-test) were realized. Results: We analyzed 365 patient records, among which 289 (79.17%) were male, and 73 (20.0%) were female. Age ranged from 16 to 101 years, with a mean of 61.13. Regarding education, 157 (43.01%) studied < 8 years, 103 (28.21%) were illiterate and 102 (27.94%) studied > 8 years. 305 (83.56%) patients live in urban areas. There was an association between high clinical-staging and low educational level. For high clinical-staging, symptomatology, tobacco, and alcohol intake as well. Conclusion: Patients with low educational levels tend to report the disease later, and their diagnostics occurred in advanced stages. Thus, specific public health policies for this population, including access to dental care to recognize the clinical signs and early diagnosis, are necessary.

https://doi.org/10.20396/bjos.v20i00.8659638
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References

Gigliotti J, Madathil S, Makhoul N. Delays in oral cavity cancer. Int J Oral Maxillofac Surg. 2019; 48(9):1131-7. doi: 10.1016/j.ijom.2019.02.015.

Dantas TS, de Barros Silva PG, Sousa EF, da Cunha MDP, de Aguiar AS, Costa FW, et al. Influence of educational level, stage, and histological type on survival of oral cancer in a brazilian population. Medicine (Baltimore). 2016; 95(3):e2314. doi: 10.1097/md.0000000000002314.

Phelan J, Link B, Diez-Roux A, Kawachi I, Levin B. “Fundamental Causes” of Social Inequalities in Mortality: A Test of the Theory. J Health Soc Behav. 2004; 45(3):265-85. doi: 10.1177/002214650404500303.

Syse A, Lyngstad T. In sickness and in health: The role of marital partners in cancer survival. SSM Popul Health. 2017; 3:99-110. doi: 10.1016/j.ssmph.2016.12.007.

Lins LS, Bezerra NV, Freire AR, Almeida LD, Lucena EH, Cavalcanti YW. Socio-demographic characteristics are related to the advanced clinical stage of oral cancer. Med Oral Patol Oral Cir Bucal. 2019; 24(6):e759-63. doi: 10.4317/medoral.23105.

Moro JS, Maroneze MC, Ardenghi TM, Barin LM, Danesi CC. Oral and oropharyngeal cancer: epidemiology and survival analysis. Einstein (Sao Paulo). 2018;16(2):1-5. doi: 10.1590/s1679-45082018ao4248.

Santos HB, dos Santos TK, Paz AR, Cavalcanti YW, Nonaka CFW, Godoy GP, et al. Clinical findings and risk factors to oral squamous cell carcinoma in young patients: a 12-year retrospective analysis. Med Oral Patol Oral y Cir Bucal. 2016;21(2):e151-6. doi: 10.4317/medoral.20770.

American Cancer Society. Cancer Facts & Figures. Atlanta: American Cancer Society; 2018.

Alves AM, Correa MB, Silva KD, Araújo LMA, Vasconcelos ACU, Gomes APN, et al. Demographic and clinical profile of oral squamous cell carcinoma from a Service-Based Population. Braz Dent J. 2017; 28(3):301-6. doi: 10.1590/0103-6440201601257.

Mathew A, George PS, Kunnambath R, Mathew BS, Kumar A, Syampramod R, et al. Educational Status, Cancer Stage, and Survival in South India: A Population-Based Study. JCO Glob Oncol. 2020;6:1704-11. doi: 10.1200/GO.20.00259.

Osazuwa-Peters N, Adjei Boakye E, Hussaini AS, Sujijantarat N, Ganesh RN, Snider M, et al. Characteristics and predictors of oral cancer knowledge in a predominantly African American community. PLoS One. 2017;17;12(5):e0177787. doi: 10.1371/journal.pone.0177787.

Vanthomme K, Vandenheede H, Hagedoorn P, Gadeyne S. Evolution of educational inequalities in site-specific cancer mortality among Belgian men between the 1990s and 2000s using a “fundamental cause” perspective. BMC Cancer. 2017;17(1):470. doi: 10.1186/s12885-017-3461-8.

Mackenbach JP, Kulhánová I, Bopp M, Deboosere P, Eikemo TA, Hoffmann R, et al. Variations in the relation between education and cause-specific mortality in 19 European populations: A test of the “fundamental causes” theory of social inequalities in health. Soc Sci Med. 2015;127:51-62. doi: 10.1016/j.socscimed.2014.05.021.

Alam M, Siddiqui S, Perween R. Epidemiological profile of head and neck cancer patients in Western Uttar Pradesh and analysis of distributions of risk factors in relation to site of tumor. J Cancer Res Ther. 2017;13(3):430-5. doi: 10.4103/0973-1482.180687.

Peltanova B, Raudenska M, Masarik M. Effect of tumor microenvironment on pathogenesis of the head and neck squamous cell carcinoma: a systematic review. Mol Cancer. 2019;18(1):63. doi: 10.1186/s12943-019-0983-5.

Logan HL, Guo Y, Marks J. Disparities in survival patterns for oral and pharyngeal cancer in Florida: can we do anything about it? Today’s FDA. 2015;27(4):58–61.

Crescenzi D, Laus M, Radici M, Croce A. TNM classification of the oral cavity carcinomas: some suggested modifications. Otolaryngol Pol. 2015;69(4):21-30. doi: 10.5604/00306657.1160919.

Alzahrani R, Obaid A, Al-Hakami H, Alshehri A, Al-Assaf H, Adas R, et al. Locally Advanced Oral Cavity Cancers: What Is The Optimal Care?. Cancer Control. 2020;27(1):1073274820920727. doi: 10.1177/1073274820920727.

Gigliotti J, Madathil S, Makhoul N. Delays in oral cavity cancer. Int J Oral Maxillofac Surg. 2019;48(9):1131-7. doi: 10.1016/j.ijom.2019.02.015.

Langton S, Cousin GCS, Plüddemann A, Bankhead CR. Comparison of primary care doctors and dentists in the referral of oral cancer: a systematic review. Br J Oral Maxillofac Surg. 2020;58(8):898-917. doi: 10.1016/j.bjoms.2020.06.009.

Ghantous Y, Yaffi V, Abu-Elnaaj I. [Oral cavity cancer: epidemiology and early diagnosis]. Refuat Hapeh Vehashinayim (1993). 2015;32(3):55-63, 71. Hebrew.

Abadeh A, Ali A, Bradley G, Magalhaes M. Increase in detection of oral cancer and precursor lesions by dentists. J Am Dent Assoc. 2019;150(6):531-9. doi: 10.1016/j.adaj.2019.01.026.

Zuniga S, Lango M. Effect of rural and urban geography on larynx cancer incidence and survival. Laryngoscope, 2018;128(8):1874-80. doi: 10.1002/lary.27042.

Roberts ME, Doogan NJ, Kurti AN, Redner R, Gaalema DE, Stanton CA, et al. Rural tobacco use across the united states: how rural and urban areas differ, broken down by census regions and divisions. Health Place. 2016;39:153-9. doi: 10.1016/j.healthplace.2016.04.001.

Arruda NM, Maia AG, Alves LC. Inequality in access to health services between urban and rural areas in Brazil: a disaggregation of factors from 1998 to 2008. Cad Saude Publica. 2018;34(6):e00213816. doi: 10.1590/0102-311x00213816.

Cunha A, Prass T, Hugo F. Mortality from oral and oropharyngeal cancer in Brazil: impact of the National Oral Health Policy. Cad Saude Publica. 2019;35(12):e00014319. doi: 10.1590/0102-311x00014319.

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