Evaluation of the potential for transmission of coronavirus disease via saliva

a systematic review and meta-analysis





COVID-19, Dental health services, Saliva


Aim: One of the main factors that play a pivotal role in the transmission of COVID-19 from human to human is saliva; according to the subject’s importance, the present study aimed to evaluate the potential of transmission via the saliva of coronavirus disease. Methods: PubMed, ISI, Embase, Scopus, Medicine have been used until September 2020 to search for articles. Therefore, EndNote X9 used to manage electronic resources. A 95% confidence interval (CI) effect size, fixed effect model, Inverse-variance methods have been calculated. The positive rate of SARS-CoV2 assessed with meta analysis. To deal with potential heterogeneity, random effects were used, and I2 showed heterogeneity. I2 values above 50% signified moderate-to-high heterogeneity. The Meta-analysis has been evaluated with Stata/MP v.16 (the fastest version of Stata) statistical software. Results: According to the study’s purpose, in the initial search with keywords, 19 articles were found, the full text of 3 studies was reviewed, and finally, three studies were selected. The positive rate of SARS-CoV2 was 86% (86%; 95% CI 67 %-100%). Conclusion: saliva can be a non-invasive specimen type for diagnosis of COVID-19. Dentists should be aware that saliva plays a major role in the transmission of COVID-19 from human to human, and failure to follow prevention protocols can contaminate them.


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Author Biographies

Ali Amiri, Xi’an Jiaotong University

Department of Orthodontics, College of Stomatology, The First Affiliated Stomatological Hospital, Xi’an Jiaotong University, Xi’an 710004, PR China.

Pantea Moradinejad, Iranian Association of Periodontology

Iranian Association of Periodontology, Tehran, Iran.

Navid Nasrabadi, Shahid Beheshti University of Medical Sciences

Department of Endodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Marzieh Ghasemi Vojoodi, Kermanshah University of Medical Sciences

School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran.


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How to Cite

Amiri A, Moradinejad P, Nasrabadi N, Ghasemi Vojoodi M. Evaluation of the potential for transmission of coronavirus disease via saliva: a systematic review and meta-analysis. Braz. J. Oral Sci. [Internet]. 2021 Feb. 8 [cited 2022 May 27];20(00):e213587. Available from: https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8663587



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