Evaluation of the potential for transmission of coronavirus disease via saliva
a systematic review and meta-analysis
Keywords:COVID-19, Dental health services, Saliva
Aim: One of the main factors that play a pivotal role in the transmission of COVID-19 from human to human is saliva; according to the subject’s importance, the present study aimed to evaluate the potential of transmission via the saliva of coronavirus disease. Methods: PubMed, ISI, Embase, Scopus, Medicine have been used until September 2020 to search for articles. Therefore, EndNote X9 used to manage electronic resources. A 95% confidence interval (CI) effect size, fixed effect model, Inverse-variance methods have been calculated. The positive rate of SARS-CoV2 assessed with meta analysis. To deal with potential heterogeneity, random effects were used, and I2 showed heterogeneity. I2 values above 50% signified moderate-to-high heterogeneity. The Meta-analysis has been evaluated with Stata/MP v.16 (the fastest version of Stata) statistical software. Results: According to the study’s purpose, in the initial search with keywords, 19 articles were found, the full text of 3 studies was reviewed, and finally, three studies were selected. The positive rate of SARS-CoV2 was 86% (86%; 95% CI 67 %-100%). Conclusion: saliva can be a non-invasive specimen type for diagnosis of COVID-19. Dentists should be aware that saliva plays a major role in the transmission of COVID-19 from human to human, and failure to follow prevention protocols can contaminate them.
Wei FF, Moradkhani A, Hemmati Hezaveh H, Miraboutalebi SA, Salehi L. Evaluating the treatment with favipiravir in patients infected by COVID-19: a systematic review and meta-analysis. Int J Sci Res Dent Med Sci. 2020;2(3):87-91. doi: 10.30485/IJSRDMS.2020.241494.1079.
Alhazzani W, Møller MH, Arabi YM, Loeb M, Gong MN, Fan E, et al. Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19). Intensive Care Med. 2020 May;46(5):854-87. https://doi.org/10.1007/s00134-020-06022-5.
Gaye B, Fanidi A, Jouven X. Denominator matters in estimating COVID-19 mortality rates. Eur Heart J. 2020 Oct 1;41(37):3500. doi: 10.1093/eurheartj/ehaa282.
Aponte Mendez M, Rivera Marval EK, Talebzade Toranji M, Amini F, Casaroto AR. Dental care for patients during the Covid-19 outbreak: a literature review. Int J Sci Res Dent Med Sci. 2020;2(2):42-5. doi:10.30485/IJSRDMS.2020.232096.1058.
Borges do Nascimento IJ, Cacic N, Abdulazeem HM, von Groote TC, Jayarajah U, Weerasekara I, et al. Novel coronavirus infection (COVID-19) in humans: a scoping review and meta-analysis. J Clin Med. 2020 Mar 30;9(4):941. doi: 10.3390/jcm9040941.
China NHC. [New Coronavirus pneumonia prevention and control protocol]. 5. ed. National Health Commission of the People's Republic of China; 2020 [cited 2020 Nov 8]. Available from: http://www.nhc.gov.cn/xcs/fkdt/202002/e84bd30142ab4d8982326326e4db22ea.shtml. Chinese
Wang J, Du G. COVID-19 may transmit through aerosol. Ir J Med Sci. 2020 Nov;189(4):1143-4. doi: 10.1007/s11845-020-02218-2.
To KK, Tsang OT, Yip CC, Chan KH, Wu TC, Chan JM, et al. Consistent detection of 2019 novel coronavirus in saliva. Clin Infect Dis. 2020 Jul;71(15):841-3. doi: 10.1093/cid/ciaa149.
Meng L, Hua F, Bian Z. Coronavirus disease 2019 (COVID-19): emerging and future challenges for dental and oral medicine. J Dent Res. 2020 May;99(5):481-7. doi: 10.1177/0022034520914246.
Williams E, Bond K, Zhang B, Putland M, Williamson DA. Saliva as a non-invasive specimen for detection of SARS-CoV-2. J Clin Microbiol. 2020 Jul 23;58(8):e00776-20. doi: 10.1128/JCM.00776-20.
Chang D, Lin M, Wei L, Xie L, Zhu G, Cruz CS, et al. Epidemiologic and clinical characteristics of novel coronavirus infections involving 13 patients outside Wuhan, China. JAMA. 2020 Mar 17;323(11):1092-3. doi: 10.1001/jama.2020.1623.
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5.
Casaroto AR, Jamali J, Amini F, Talebzade Toranji M, Kayasöken G. Evaluation epidemiology, symptoms, and routes of COVID-19 for Dental care: a literature review. Int J Sci Res Dent Med Sci.2020;2(2):37-41. doi: 10.30485/IJSRDMS.2020.231680.1056.
Zemouri C, de Soet H, Crielaard W, Laheij A. A scoping review on bio-aerosols in healthcare and the dental environment. PloS one. 2017;12(5):e0178007. doi.:10.1371/journal.pone.0178007.
Bahl P, Doolan C, de Silva C, Chughtai AA, Bourouiba L, MacIntyre CR. Airborne or droplet precautions for health workers treating COVID-19? J Infect Dis. 2020 Apr 16;jiaa189. doi: 10.1093/infdis/jiaa189.
Morawska L, Tang JW, Bahnfleth W, Bluyssen PM, Boerstra A, Buonanno G, et al. How can airborne transmission of COVID-19 indoors be minimised? Environ Int. 2020 Sep;142:105832. doi: 10.1016/j.envint.2020.105832.
Gu J, Han B, Wang J. COVID-19: gastrointestinal manifestations and potential fecal–oral transmission. Gastroenterology. 2020 May;158(6):1518-9. doi: 10.1053/j.gastro.2020.02.054.
Singhal T. A review of coronavirus disease-2019 (COVID-19). Indian J Pediatr. 2020 Apr;87(4):281-6. doi: 10.1007/s12098-020-03263-6.
World Helath Organization. Emergencies preparedness, response. Pneumonia of unknown origin–China. Disease outbreak news. 2020 Jan 5 [cited 2020 Nov 20]. Available from: https://www.who.int/csr/don/05-january-2020-pneumonia-of-unkown-cause-china/en.
Sabino-Silva R, Jardim AC, Siqueira WL. Coronavirus COVID-19 impacts to dentistry and potential salivary diagnosis. Clin Oral Investig. 2020 Apr;24(4):1619-1621. doi: 10.1007/s00784-020-03248-x.
Stoecklin SB, Rolland P, Silue Y, Mailles A, Campese C, Simondon A, et al. First cases of coronavirus disease 2019 (COVID-19) in France: surveillance, investigations and control measures, January 2020. Euro Surveill. 2020 Feb;25(6):2000094. doi: 10.2807/1560-7917.ES.2020.25.6.2000094.
Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020 Feb 20;382(8):727-733. doi: 10.1056/NEJMoa2001017.
Xie X, Li Y, Sun H, Liu L. Exhaled droplets due to talking and coughing. J R Soc Interface. 2009 Dec;6 Suppl 6(Suppl 6):S703-14. doi: 10.1098/rsif.2009.0388.focus.
Organization WH. Global Surveillance for human infection with novel coronavirus (2019-nCoV): interim guidance, 31 January 2020 [cited 2020 Nov 20]. Available from: https://apps.who.int/iris/handle/10665/330857.
Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. JAMA. 2020 Mar 17;323(11):1061-9. doi: 10.1001/jama.2020.1585.
Thoracic S. [Expert consensus for bronchoscopy during the epidemic of 2019 novel coronavirus infection (Trial version)]. Zhonghua Jie He He Hu Xi Za Zhi. 2020 Mar 12;43(3):199-202. doi: 10.3760/cma.j.issn.1001-0939.2020.03.012. Chinese.
World Helath Organization. Infection prevention and control of epidemic-and pandemic-prone acute respiratory infections in health care. 2014 Apr 7 [cited 2020 Nov 20]. Available from: https://www.who.int/publications/i/item/infection-prevention-and-control-of-epidemic-and-pandemic-prone-acute-respiratory-infections-in-health-care.
Otter JA, Yezli S, Salkeld JA, French GL. Evidence that contaminated surfaces contribute to the transmission of hospital pathogens and an overview of strategies to address contaminated surfaces in hospital settings. Am J Infect Control. 2013 May;41(5 Suppl):S6-11. doi: 10.1016/j.ajic.2012.12.004.
Baghizadeh Fini, M. Transmission routes of SARS-CoV-2 in dentistry: a literature review. Int J Sci Res Dent Med Sci. 2020;2(4):135-7. doi: 10.30485/ijsrdms.2020.252402.1088.
Zuanazzi D, Arts EJ, Jorge PK, Mulyar Y, Gibson R, Xiao Y, et al. Postnatal identification of Zika virus peptides from saliva. J Dent Res. 2017 Sep;96(10):1078-1084. doi: 10.1177/0022034517723325.
Barzon L, Pacenti M, Berto A, Sinigaglia A, Franchin E, Lavezzo E, et al. Isolation of infectious Zika virus from saliva and prolonged viral RNA shedding in a traveller returning from the Dominican Republic to Italy, January 2016. Euro Surveill. 2016;21(10):30159. doi: 10.2807/1560-7917.ES.2016.21.10.30159.
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