Triclosan antimicrobial activity against dental-caries-related bacteria




Triclosan, Streptococcus mutans, Dental caries


Triclosan (TCS) is a chlorinated diphenyl ether and a possible active agent against microorganisms. Due to its probability of reducing dental plaque accumulation, TCS can be added as a substance for oral hygiene. Aim: To evaluate the efficacy and antimicrobial capacity of TCS against Pseudomonas aeruginosa and Streptococcus mutans. Methods: This work evaluates the percentage of bacteria inhibition of P. aeruginosa (ATCC 27853) and S. mutans (ATCC 25175). TCS concentrations between 2 and 128 μg.mL-1 were tested. Results: An inhibitory potential of TCS was found against S. mutans. No percentage of inhibition was detected against P. aeruginosa (technical and biological triplicate). Conclusion: TCS, an antimicrobial agent used in dentifrices, can reduce S. mutans levels therefore these dentifrices should be indicated for patients with a high risk of caries. However, further study is needed, including antimicrobial analyses against other microbial conditions.


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Author Biographies

Jade Ormondes de Farias, University of Brasília

Postgraduate in Health Sciences, Faculty of Health Sciences, University of Brasília, Campus Darcy Ribeiro, Asa Norte, Brasília, DF, Brazil.

Jamilca de Almeida do Espírito Santo, Catholic University of Brasilia

Dentistry Course, Catholic University of Brasilia, Brasília. DF, Brazil.

Ingrid Aquino Amorim, Catholic University of Brasília

Postgraduate in Genomic Sciences and Biotechnology, Catholic University of Brasília, Asa Norte, Brasília, DF. Brazil.

Taia Maria Berto Rezende, Catholic University of Brasilia

Postgraduate in Health Sciences, Faculty of Health Sciences, University of Brasília, Campus Darcy Ribeiro, Asa Norte, Brasília, DF, Brazil. Dentistry Course, Catholic University of Brasilia, Brasília. DF, Brazil.




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How to Cite

Farias JO de, Santo J de A do E, Amorim IA, Rezende TMB. Triclosan antimicrobial activity against dental-caries-related bacteria. Braz. J. Oral Sci. [Internet]. 2022 Sep. 13 [cited 2022 Dec. 5];22(00):e238076. Available from:



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