Keywords
Anti-bacterial agents
Surgical wound infection
Oral and maxillofacial surgeons
Dental Focal infection
How to Cite
Abstract
Aim: To investigate the bacteriological profile of oral and maxillofacial infections and the pattern of sensitivity to a specific group of antibiotics in a reference emergency hospital in Brazil. Methods: This is a prospective cohort institutional study that studied patients affected by oral and/ or maxillofacial infections in a Brazilian emergency hospital, over a 12-month period, of different etiologies, through data collection, culture and antibiogram tests, and monitoring of the process of resolution of the infectious condition. The variables were analyzed using the chi-square and Mann-Whitney tests, using a significance level of 5%. Results: The sample consisted of 61 patients, 62.3% male. The mean age of participants was 34.3 years. Odontogenic infection was the most frequent etiology and the submandibular space was the most affected. The bacterial species Streptococcus viridans was isolated in 21.6% of cases. Levofloxacin, vancomycin and penicillin were the antibiotics with the highest frequency of bacterial sensitivity, while clindamycin and erythromycin showed the highest percentages of resistance. Conclusions: The results suggest that, among the most used antibiotics for the treatment of these infections, penicillin remains an excellent option of choice for empirical therapy.
References
- Dai T, Cheng J, Ran H, Xu B, Liu Y, Qiu Y. Application of disposable multifunctional drainage tube-assisted irrigation in patients with severe multi-space infections in oral and maxillofacial head and neck regions. J Craniofac Surg. 2020 Mar/Apr;31(2):e202-5. doi: 10.1097/SCS.0000000000006236.
- Kim MK, Chuang SK, August M. Antibiotic resistance in severe orofacial infections. J Oral Maxillofac Surg. 2017 May;75(5):962-8. doi: 10.1016/j.joms.2016.10.039.
- Ogle OE. Odontogenic infections. Dent Clin North Am. 2017 Apr;61(2):235-52. doi: 10.1016/j.cden.2016.11.004.
- Adamson OO, Adeyemi MO, Gbotolorun OM, Oduyebo OO, Odeniyi O, Adeyemo WL. Comparison of sensitivity of bacteria isolated in odontogenic infections to ceftriaxone and amoxicillin-clavulanate. Afr Health Sci. 2019 Sep;19(3):2414-20. doi: 10.4314/ahs.v19i3.15.
- Gómez-Arámbula H, Hidalgo-Hurtado A, Rodríguez-Flores R, González-Amaro AM, Garrocho-Rangel A, Pozos-Guillén A. Moxifloxacin versus Clindamycin/Ceftriaxone in the management of odontogenic maxillofacial infectious processes: a preliminary, intrahospital, controlled clinical trial. J Clin Exp Dent. 2015 Dec;7(5):e634-9. doi: 10.4317/jced.52627.
- Kumari S, Mohanty S, Sharma P, Dabas J, Kohli S, Diana C. Is the routine practice of antibiotic prescription and microbial culture and antibiotic sensitivity testing justified in primary maxillofacial space infection patients? A prospective, randomized clinical study. J Cranio-Maxillofac Surg. 2018 Mar;46(3):446-52. doi: 10.1016/j.jcms.2017.11.026.
- Ibiyemi ST, Okoje-Adesomoju VN, Dada-Adegbola HO, Arotiba JT. Pattern of orofacial bacterial infections in a Tertiary Hospital in Southwest, Nigeria. J West African Coll Surg. 2014 Oct-Dec;4(4):112-41.
- Juncar M, Juncar RI, Onisor-Gligor F. Ludwig’s angina, a rare complication of mandibular fractures. J Int Med Res. 2019 May;47(5):2280-7. doi: 10.1177/0300060519840128.
- Kang SH, Kim MK. Antibiotic sensitivity and resistance of bacteria from odontogenic maxillofacial abscesses. J Korean Assoc Oral Maxillofac Surg. 2019 Dec;45(6):324-31. doi: 10.5125/jkaoms.2019.45.6.324.
- Taub D, Yampolsky A, Diecidue R, Gold L. Controversies in the Management of Oral and Maxillofacial Infections. Oral Maxillofac Surg Clin North Am. 2017 Nov;29(4):465-73. doi: 10.1016/j.coms.2017.06.004.
- Sebastian A, Antony PG, Jose M, Babu A, Sebastian J, Kunnilathu A. Institutional microbial analysis of odontogenic infections and their empirical antibiotic sensitivity. J Oral Biol Craniofacial Res. 2019 Apr-Jun;9(2):133-8. doi: 10.1016/j.jobcr.2019.02.003.
- Plum AW, Mortelliti AJ, Walsh RE. Microbial flora and antibiotic resistance in odontogenic abscesses in Upstate New York. Ear Nose Throat J. 2018 Jan-Feb;97(1-2):E27-E31. doi: 10.1177/0145561318097001-207.
- Juncar M, Onişor-Gligor F, Bran S, Juncar RI, Băciuţ MF, Dumitraşcu DI, et al. Efficiency of empirically administered antibiotics in patients with cervical infections of odontogenic origin. Clujul Med 2015;88(1):65-8. doi: 10.15386/cjmed-399.
- Liau I, Han J, Bayetto K, May B, Goss A, Sambrook P, et al. Antibiotic resistance in severe odontogenic infections of the South Australian population: a 9-year retrospective audit. Aust Dent J. 2018 Jun;63(2):187-92. doi: 10.1111/adj.12607.
- Jagadish Chandra H, Sripathi Rao BH, Muhammed Manzoor AP, Arun AB. Characterization and antibiotic sensitivity profile of bacteria in orofacial abscesses of odontogenic origin. J Maxillofac Oral Surg. 2017 Dec;16(4):445-52. doi: 10.1007/s12663-016-0966-7.
- Singh M, Kambalimath DH, Gupta KC. Management of odontogenic space infection with microbiology study. J Maxillofac Oral Surg. 2014 Jun;13(2):133-9. doi: 10.1007/s12663-012-0463-6.
- Farmahan S, Tuopar D, Ameerally PJ. A study to investigate changes in the microbiology and antibiotic sensitivity of head and neck space infections. Surgeon. 2015 Dec;13(6):316-20. doi: 10.1016/j.surge.2014.02.006.
- Park J, Lee JY, Hwang DS, Kim YD, Shin SH, Kim UK, et al. A retrospective analysis of risk factors of oromaxillofacial infection in patients presenting to a hospital emergency ward. Maxillofac Plast Reconstr Surg. 2019 Nov;41(1):49. doi: 10.1186/s40902-019-0238-9.
- Dahlén G. Non-odontogenic infections in dentistry. Periodontol 2000. 2009 Feb;49(1):7-12. doi: 10.1111/j.1600-0757.2008.00298.x.
- Götz C, Reinhart E, Wolff KD, Kolk A. Oral soft tissue infections: causes, therapeutic approaches and microbiological spectrum with focus on antibiotic treatment. J Cranio-Maxillofac Surg. 2015 Nov;43(9):1849-54. doi: 10.1016/j.jcms.2015.08.002.
- Rasteniene R, Puriene A, Aleksejuniene J, Pečiuliene V, Zaleckas L. Odontogenic maxillofacial infections: a ten-year retrospective analysis. Surg Infect (Larchmt). 2015 Jun;16(3):305-12. doi: 10.1089/sur.2013.264.
- López-González E, Vitales-Noyola M, González-Amaro AM, Méndez-González V, Hidalgo-Hurtado A, Rodríguez-Flores R, et al. Aerobic and anaerobic microorganisms and antibiotic sensitivity of odontogenic maxillofacial infections. Odontology. 2019 Jul;107(3):409-17. doi: 10.1007/s10266-019-00414-w.
- Shakya N, Sharma D, Newaskar V, Agrawal D, Shrivastava S, Yadav R. Epidemiology, microbiology and antibiotic sensitivity of odontogenic space infections in central India. J Maxillofac Oral Surg. 2018 Sep;17(3):324-31. doi: 10.1007/s12663-017-1014-y.
- Shah A, Ramola V, Nautiyal V. Aerobic microbiology and culture sensitivity of head and neck space infection of odontogenic origin. Natl J Maxillofac Surg. 2016 Jan-Jun;7(1):56-61. doi: 10.4103/0975-5950.196126.
- Fating NS, Saikrishna D, Vijay Kumar GS, Shetty SK, Raghavendra Rao M. Detection of bacterial flora in orofacial space infections and their antibiotic sensitivity profile. J Maxillofac Oral Surg. 2014 Dec;13(4):525-32. doi: 10.1007/s12663-013-0575-7.
- Zhang C, Tang Y, Zheng M, Yang J, Zhu G, Zhou H, et al. Maxillofacial space infection experience in West China: a retrospective study of 212 cases. Int J Infect Dis. 2010 May;14(5):e414-7. doi: 10.1016/j.ijid.2009.08.002.
- Yuvaraj V, Alexander M, Pasupathy S. Microflora in maxillofacial infections-A changing scenario? J Oral Maxillofac Surg. 2012 Jan;70(1):119-25. doi: 10.1016/j.joms.2011.02.006.
- Kityamuwesi R, Muwaz L, Kasangaki A, Kajumbula H, Rwenyonyi CM. Characteristics of pyogenic odontogenic infection in patients attending Mulago Hospital, Uganda: a cross-sectional study. BMC Microbiol. 2015 Feb:15:46. doi: 10.1186/s12866-015-0382-z.
- Weise H, Naros A, Weise C, Reinert S, Hoefert S. Severe odontogenic infections with septic progress - A constant and increasing challenge: a retrospective analysis. BMC Oral Health. 2019 Aug;19(1):173. doi: 10.1186/s12903-019-0866-6.
- Heim N, Faron A, Wiedemeyer V, Reich R, Martini M. Microbiology and antibiotic sensitivity of head and neck space infections of odontogenic origin. Differences in inpatient and outpatient management. J Cranio-Maxillofac Surg. 2017 Oct;45(10):1731-5. doi: 10.1016/j.jcms.2017.07.013.
- Patankar A, Dugal A, Hariram H, Kshirsagar R, Mishra A, Singh V. Evaluation of microbial flora in orofacial space infections of odontogenic origin. Natl J Maxillofac Surg. 2014 Jul-Dec;5(2):161-5. doi: 10.4103/0975-5950.154820.
- Walia IS, Borle RM, Mehendiratta D, Yadav AO. Microbiology and antibiotic sensitivity of head and neck space infections of odontogenic origin. J Maxillofac Oral Surg. 2014 Mar;13(1):16-21. doi: 10.1007/s12663-012-0455-6.
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Copyright (c) 2024 Laiz Moreira de Paula, Eduardo Zancopé
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