Keywords
S100 proteins
Immunohistochemistry
Mouth neoplasms
How to Cite
Abstract
Aim: To report a case of non-neural granular cell tumor (NN-GCT), an uncommon neoplasm, with only six studies worldwide describing cases involving the oral cavity. Methods: A 26-year-old male patient with an erythematous, firm, polypoid nodule in the floor of the mouth that exhibited areas of ulceration and mild bleeding to the touch. A biopsy was performed to aid in the diagnosis. Results: Based on the histopathological and immunohistochemical results (vimentin +, CD68 +, S100 -), the diagnosis was compatible with S100-negative (primitive polypoid non-neural) granular cell tumor. No recurrence was observed over two years of follow-up. Conclusion: The diagnosis of NN-GCT is extremely challenging because this tumor shares histological and immunophenotypic features with many benign and malignant tumors. Although oral NN-GCT may exhibit unusual and atypical histological features, it has an indolent behavior. Thus, until more cases of oral involvement are reported, complete resection and close follow-up are recommended.
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This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2024 Larisssa Abbehusen Couto, Daiana Cristina Pereira Santana, Ianna Josefa Valeska de Aniz Castro, Roberto Almeida de Azevedo, Flávia Caló de Aquino Xavier, Jean Nunes dos Santos, Águida Cristina Gomes Henriques Leitão
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