Particularidades dos diferentes tecidos adiposos

implicações metabólicas na obesidade

Autores

DOI:

https://doi.org/10.20396/conex.v17i0.8653471

Palavras-chave:

Tecido adiposo, Distribuição da gordura corporal, Obesidade abdominal

Resumo

Objetivo: apresentar os possíveis mecanismos fisiológicos envolvidos na regulação metabólica pelo tecido adiposo conforme sua particularidade celular. Métodos: para isso, realizou-se uma revisão da literatura, utilizando a base de dados Medical Literature Analysis and Retrieval System Online (Medline/PubMed) considerando publicações a partir de 2007. Resultados e Discussão:como resultado da revisão de literatura foram identificados quatro abordagens principais que tratam da influência dos diferentes depósitos de gordura no estado metabólico: 1- Características Fisiológicas dos Adipócitos; 2- Teoria Portal; 3- Hipótese da Expansão do Adipócito; 4- Relação da Expansão do Adipócito com a Inflamação e Fatores Adversos. Conclusão: nesse sentido, as evidências têm apontado que a distribuição da gordura corporal associada as caracteristícas moleculares, função e localização específicas dos diferentes tipos de adipócitos podem ser mais determinantes que a quantidade total de gordura corporal, no que diz respeito ao estabelecimento de um perfil metabólico mais saudável.

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Biografia do Autor

Eliézer Guimarães Moura, Centro Universitário Adventista de São Paulo

Docente no curso de Educação Física do Centro Universitário Adventista de São Paulo. Doutorando em Educação Física pela Universidade Estadual de Campinas.

Keryma Chaves da Silva Mateus, Universidade Estadual de Campinas

Doutoranda em Educação Física pela Faculdade de Educação Física, Laboratório de Fisiologia do Exercício - Universidade Estadual de Campinas.

Patricia Berilli Batista, Universidade Estadual de Campinas

Doutoranda em Alimentos e Nutrição no Departamento de Alimentos e Nutrição da Faculdade de Engenharia de Alimentos, Universidade Estadual de Campinas.

Ivan Luiz Padilha Bonfante, Universidade Estadual de Campinas

Doutorando em Educação Física pelo Laboratório de Fisiologia do Exercício da Faculdade de Educação Física - Universidade Estadual de Campinas.

Érica Cristina Godoi, Universidade Estadual de Campinas

Graduada em Fisioterapia pela Pontifícia Universidade Católica de Campinas. Pós-graduanda no Programa de Residência Multiprofissional pela Universidade Estadual de Campinas.

Mariane Rodrigues dos Santos, Universidade Estadual de Campinas

Graduação em Educação Física pela Faculdade de Educação Física, Laboratório de Fisiologia do Exercício - Universidade Estadual de Campinas.

Olivia Moraes Ruberti, Universidade Estadual de Campinas

Doutoranda em Biologia Funcional e Molecular no Departamento de Biologia Funcional e Estrutura - Instituto de Biologia – Universidade Estadual de Campinas.

Referências

ACKERMAN, Daniel, GEMS, David. The mystery of C. elegans aging: an emerging role for fat. Distant parallels between C. elegans aging and metabolic syndrome? Bioessays, v. 34, n. 6, p. 466–71, 2012. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/22371137.

ANDERSSON, Daniel P et al. Omentectomy in addition to gastric bypass surgery and influence on insulin sensitivity: a randomized double blind controlled trial. Clinical Nutrition, v. 33, n. 6, p. 991–6, 2014. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/24485000.

ANDERSSON, Daniel P et al. Omentectomy in addition to bariatric surgery-a 5-Year follow-up. Obesity Surgery, v. 27, n. 4, p. 1115–8, 2017. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/28155057.

ARNER, Erik et al. Adipocyte turnover: relevance to human adipose tissue morphology. Diabetes, v. 59, n. 1, p. 105–9, 2010. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/19846802.

BAYS, Harold. Central obesity as a clinical marker of adiposopathy; increased visceral adiposity as a surrogate marker for global fat dysfunction. Current Opinion in Endocrinology, Diabetes, and Obesity, v. 21, n. 5, p. 345–51, 2014. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/25106000.

BELFIORE, Antonino et al. Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease. Endocrine Reviews, v. 30, n. 6, p. 586–623, 2009. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/19752219.

BERNDT J, et al. Adipose triglyceride lipase gene expression in human visceral obesity. Exp Clin Endocrinol Diabetes, v. 116, n. 4, p. 203–10, 2008. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/18072017.

BOONCHAYA-ANANT, Patchaya; APOVIAN, Caroline M. Metabolically healthy obesity--does it exist?. Current Atherosclerosis Reports, v. 16, n. 10, p. 441, 2014. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/25092577.

BOOTH, Andrea; MAGNUSON, Aaron; FOSTER, Michelle. Detrimental and protective fat: body fat distribution and its relation to metabolic disease. Hormone Molecular Biology and Clinical Investigation, v. 17, n. 1, p. 13–27, 2014. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/25372727.

BOSTROM, Pontus et al. A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature, v. 481, n. 7382, p. 463–8, 2012. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/22237023.

BRASIL. Ministério da Saúde. Secretaria de Vigilância em Saúde, Departamento de Vigilância de Doenças e Agravos não Transmissíveis e Promoção da Saúde. Vigilância de fatores de risco e proteção para doenças crônicas por inquérito telefônico (VIGITEL): estimativas sobre frequência e distribuição sociodemográfica de fatores de risco e proteção para doenças crônicas nas capitais dos 26 estados. 2016.

CARTWRIGHT, Mark J; TCHKONIA, Tamara; KIRKLAND, James L. Aging in adipocytes: potential impact of inherent, depot-specific mechanisms. Experimental Gerontology, v. 42, n. 6, p. 463–71, 2007. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/17507194.

CEDIKOVA, Miroslava et al. Mitochondria in white, brown, and beige adipocytes. Stem Cells International, v. 2016, p 1–11, 2016. Disponível em: https://www.hindawi.com/journals/sci/2016/6067349/.

CHMELAR, Jindrich; CHUNG, Kyoung-Jin; CHAVAKIS, Triantafyllos. The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance. Thrombosis and Haemostasis, v. 109, n. 3, p. 399–406, 2013. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/23364297.

CYPESS, Aaron M et al. Identification and importance of brown adipose tissue in adult humans. New England Journal of Medicine, v. 360, n. 15, p. 1509–17, 2009. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/19357406.

de FERRANTI, Sarah; MOZAFFARIAN, Dariush. The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences. Clinical Chemistry, v. 54, n. 6, p. 945–55, 2008. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/18436717.

DENIS, Gerald V; OBIN, Martin S. “Metabolically healthy obesity”: origins and implications. Molecular Aspects of Medicine, v. 34, n. 1, p. 59–70, 2013. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/23068072.

DESPRES, Jean-Pierre; LEMIEUX, Isabelle. Abdominal obesity and metabolic syndrome. Nature, v. 444, n. 7121, p. 881–7, 2006. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/17167477.

DILLARD, Troy H et al. Omentectomy added to Roux-en-Y gastric bypass surgery: a randomized, controlled trial. Surgery for Obesity and Related Diseases, v. 9, n. 2, p. 269–75, 2013. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/22118842.

FLIER, J S. The adipocyte: storage depot or node on the energy information superhighway?. Cell, n. 80, v. 1, p. 15–18, 1995. Disponível em: https://www.sciencedirect.com/science/article/pii/009286749590445X.

FONTANA, Luigi et al. Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes, v. 56, n. 4, p.1010–3, 2007. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/17287468.

FOSTER, Michelle T et al. Transplantation of non-visceral fat to the visceral cavity improves glucose tolerance in mice: investigation of hepatic lipids and insulin sensitivity. Diabetologia, n. 54, v. 11, p. 2890–9, 2011. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/21805228.

FOSTER, Michelle T et al. Subcutaneous adipose tissue transplantation in diet-induced obese mice attenuates metabolic dysregulation while removal exacerbates it. Physiological Reports, v. 1, n. 2, p. 1–15, 2013. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/23914298.

FRÜHBECK, Gema et al. Regulation of adipocyte lipolysis. Nutrition Research Reviews, v. 27, n. 1, p. 63–93, 2014. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/24872083.

GAGGINI, Melania; SAPONARO, Chiara; GASTALDELLI, Amalia A. Not all fats are created equal: adipose vs. ectopic fat, implication in cardiometabolic diseases. Hormone Molecular Biology and Clinical Investigation, v. 22, n. 1, p. 7–18, 2015. Disponível em: Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/25816312.

GAN, Zhen-Shun et al. Iron reduces M1 macrophage polarization in RAW264. 7 macrophages associated with inhibition of STAT1. Mediators of inflammation, v. 2017, 2017. Disponível em: https://www.hindawi.com/journals/mi/2017/8570818/.

GARCIA-RUIZ, Inmaculada et al. Omentectomy prevents metabolic syndrome by reducing appetite and body weight in a diet-induced obesity rat model. Scientific Reports, v. 8, n. 1540, p. 1-13, 2018. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/29367725.

GEALEKMAN, Olga et al. Depot-specific differences and insufficient subcutaneous adipose tissue angiogenesis in human obesity. Circulation, v. 123, n. 2, p. 186–94, 2011. Disponível em: https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.110.970145.

GREGOR, Margaret F; HOTAMISLIGIL, Gokhan S. Inflammatory mechanisms in obesity. Annual Review of Immunology, v. 29, p. 415–45, 2011. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/21219177.

HERRERA, Miguel F et al. Potential additional effect of omentectomy on metabolic syndrome, acute-phase reactants, and inflammatory mediators in grade III obese patients undergoing laparoscopic Roux-en-Y gastric bypass: a randomized trial. Diabetes Care, v. 33, v. 7, p. 1413–8, 2010. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/20587720.

HISHINUMA, Akiko; MAJIMA, Mitsuru; KURABAYASHI, Hitoshi. Insulin resistance in patients with stroke is related to visceral fat obesity and adipocytokines. Journal of Stroke & Cerebrovascular Diseases, v. 17, n. 4, p. 175–80, 2008. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/18589336.

HOCKING, Samantha L et al. Subcutaneous fat transplantation alleviates diet-induced glucose intolerance and inflammation in mice. Diabetologia, v. 58, n. 7, p. 1587–600, 2015. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/25899451

HOLDSWORTH, Stephen R.; GAN, Poh-Yi. Cytokines: names and numbers you should care about. Clinical Journal of the American Society of Nephrology, v. 10, n. 12, p. 2243-2254, 2015. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/25941193.

ITEM, F; KONRAD, D. Visceral fat and metabolic inflammation: the portal theory revisited. Obesity Reviews, v. 13, n. 2, p. 30–9, 2012. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/23107257.

KUK, Jennifer L, et al. Age-related changes in total and regional fat distribution. Ageing Research Reviews, v. 8, n. 4, p.339–48, 2009. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/19576300.

LEE, Jongsoon. Adipose tissue macrophages in the development of obesity-induced inflammation, insulin resistance and type 2 diabetes. Archives of Pharmacal Research, v. 36, n. 2, p. 208–22, 2013. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/23397293.

LEE, Paul et al. Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans. Cell Metabolism, v. 19, n. 2, p. 302–9, 2014. Disponível em: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(14)00006-0?bid=98JHV5F.

LE LAY, Soazig; DUGAIL, Isabelle. Connecting lipid droplet biology and the metabolic syndrome. Progress in Lipid Research, v. 48, n. 3–4, p. 191–5, 2009. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/19303902.

LIU, Pei-Yang et al. Evidence for the association between abdominal fat and cardiovascular risk factors in overweight and obese African American women. Journal of the American College of Nutrition, v. 31, n. 2, p. 126–32, 2012. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/22855918.

LOTTATI, Maya et al. Greater omentectomy improves insulin sensitivity in nonobese dogs. Obesity (Silver Spring), v. 17, n. 4, p. 674–80, 2009. Disponível em:

MATTSON, Mark P. Perspective: Does brown fat protect against diseases of aging? Ageing Research Reviews, v.9, n. 1, p. 69–76, 2010. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818667/.

MOSS, Anja et al. Sonographically assessed intra-abdominal fat and cardiometabolic risk factors in adolescents with extreme obesity. Obesity Facts, v. 9, n. 2, p. 121–37, 2016. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644824/.

OPAL, Steven Michael.; DEPALO, Vera A. Anti-inflammatory cytokines. Chest, v. 117, n. 4, p. 1162-1172, 2000. Disponível em: https://journal.chestnet.org/article/S0012-3692(15)32820-8/abstract.

PALIKARAS, Konstantinos, et al. Ectopic fat deposition contributes to age-associated pathology in Caenorhabditis elegans. Journal of Lipid Research, v. 58, n. 1, p. 72–80, 2017. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/27884963.

PASARICA, Magdalena et al. Reduced adipose tissue oxygenation in human obesity: evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response. Diabetes, v. 58, n. 3, p. 718–25, 2009. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/19074987.

PATEL, Pavankumar; ABATE, Nicola. Body fat distribution and insulin resistance. Nutrients, v. 5, n. 6, p. 2019–27, 2013. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725490/.

PRIMEAU, V et al. Characterizing the profile of obese patients who are metabolically healthy. International Journal of Obesity (Lond), v. 35, n. 7, p. 971–81, 2011. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/20975726.

ROSEN, Clifford J et al. Marrow fat and the bone microenvironment: developmental, functional, and pathological implications. Critical Reviews in Eukaryotic Gene Expression, v. 19, n. 2, p. 109–24, 2009. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/19392647.

ROSEN, Evan D; SPIEGELMAN, Bruce M. What we talk about when we talk about fat. Cell, v. 156, n.1-2, p. 20–44, 2014. Disponível em: https://www.cell.com/abstract/S0092-8674(13)01546-8.

RYTKA, Julia M et al. The portal theory supported by venous drainage-selective fat transplantation. Diabetes, v. 60, n. 1, p. 56–63, 2011. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/20956499.

SDRALIS, El et al. A prospective randomized study comparing patients with morbid obesity submitted to sleeve gastrectomy with or without omentectomy. Obesity Surgery, v. 23, n. 7, p. 965–71, 2013. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/23526069.

SERRA, MC; RYAN, AS; GOLDBERG, AP. Reduced LPL and subcutaneous lipid storage capacity are associated with metabolic syndrome in postmenopausal women with obesity. Obesity Science & Practice, v. 3, n. 1, p. 106–14, 2017. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/28392937.

SHEN, Wei et al. Adipose tissue quantification by imaging methods: a proposed classification. Obesity research, v. 11, n. 1, p. 5–16, 2003. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1894646/.

SKURK, Thomas et al. Relationship between adipocyte size and adipokine expression and secretion. Journal of Clinical Endocrinology & Metabolism, v. 92, n. 3, p. 1023–33, 2007. Disponível em: https://academic.oup.com/jcem/article/92/3/1023/2597680.

SORISKY, Alexander. A new predictor for type 2 diabetes? Canadian Medical Association Journal, v. 178, n. 3, p. 313–5, 2008. Disponível em: http://www.cmaj.ca/content/178/3/313.

SNIDERMAN, Allan D et al. Why might South Asians be so susceptible to central obesity and its atherogenic consequences? The adipose tissue overflow hypothesis. International Journal of Epidemiology, v. 36, n. 1, p. 220–5, 2007. Disponível em: https://academic.oup.com/ije/article/36/1/220/666373.

STANFORD, Kristin I et al. Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. Journal of Clinical Investigation, v. 123, n. 1, p. 215–23, 2013. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/23221344.

SULLIVAN, Catherine A et al. Change in intra-abdominal aat predicts the risk of hypertension in japanese americans. Hypertension, v. 66, n. 1, p. 134–40, 2015. Disponível em: https://www.ahajournals.org/doi/full/10.1161/HYPERTENSIONAHA.114.04990.

SUN, Kai; KUSMINSKI, Christine M; SCHERER, Philipp E. Adipose tissue remodeling and obesity. Journal of Clinical Investigation, v. 121, n. 6, p. 2094–101, 2011. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/21633177.

TAN, Chong Yew; VIDAL-PUIG, Antonio. Adipose tissue expandability: the metabolic problems of obesity may arise from the inability to become more obese. Biochemical Society Transactions. V. 36, n. 5, p. 935–40, 2008. Disponível em: http://www.biochemsoctrans.org/content/36/5/935.

TCHERNOF, Andre; DESPRES, Jean-Pierre. Pathophysiology of human visceral obesity: an update. Physiological Reviews, n. 93, v. 1, p. 359–404, 2013. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/23303913.

TCHKONIA, Tamara, et al. Fat tissue, aging, and cellular senescence. Aging Cell, v.9, n. 5, p. 667–84, 2010. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941545/.

THOMOU, Thomas; TCHKONIA, Tamara; JAMES, L. Kirkland. Cellular and molecular basis of functional differences among fat depots. In: Adipose Tissue in Health and Disease. Wiley-Blackwell: Hoboken, New Jersey; p. 21–47, 2010. Disponível em: https://onlinelibrary.wiley.com/doi/10.1002/9783527629527.ch2.

TORRES-VILLALOBOS, Gonzalo et al. Autologous subcutaneous adipose tissue transplants improve adipose tissue metabolism and reduce insulin resistance and fatty liver in diet-induced obesity rats. Physiological Reports, v. 4, n. 17, p. 1-14 , 2016. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/27582062.

VILLARET, Aurelie et al. Adipose tissue endothelial cells from obese human subjects: differences among depots in angiogenic, metabolic, and inflammatory gene expression and cellular senescence. Diabetes, v. 59, n. 11, p. 2755–63, 2010. Disponível em: https://diabetes.diabetesjournals.org/content/59/11/2755.

VIRTUE, Samuel; VIDAL-PUIG, Antonio. It’s not how fat you are, it’s what you do with it that counts. PLOS Biology, v. 6, n. 9, p. 1819–23, 2008. Disponível em: https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.0060237.

WHO. World Health Organization. Obesity and overweight. 2017. Disponível em: http://www.who.int/mediacentre/factsheets/fs311/en/. Acesso em: <8 de junho de 2017.

WU, Jun et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell, v. 150, n. 2, p. 366–76, 2012. Disponível em: https://www.cell.com/abstract/S0092-8674(12)00595-8.

XIA, Lu et al. Endoscopic visceral fat removal as therapy for obesity and metabolic syndrome: a sham-controlled pilot study (with video). Gastrointestinal Endoscopy, v. 74 , n. 3, p. 637–44, 2011. Disponível em: https://www.giejournal.org/article/S0016-5107(11)01932-8/abstract.

YOU, Tongjian et al. Effects of exercise training on chronic inflammation in obesity : current evidence and potential mechanisms. Sports Medicine, v. 43, n. 4, p. 243–56, 2013. Disponível em: https://link.springer.com/article/10.1007%2Fs40279-013-0023-3.

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2019-08-19

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MOURA, E. G.; MATEUS, K. C. da S.; BATISTA, P. B.; BONFANTE, I. L. P.; GODOI, Érica C.; SANTOS, M. R. dos; RUBERTI, O. M. Particularidades dos diferentes tecidos adiposos: implicações metabólicas na obesidade. Conexões, Campinas, SP, v. 17, p. e019019, 2019. DOI: 10.20396/conex.v17i0.8653471. Disponível em: https://periodicos.sbu.unicamp.br/ojs/index.php/conexoes/article/view/8653471. Acesso em: 6 dez. 2021.

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